دانلود مقاله ISI انگلیسی شماره 100627
کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
100627 2018 6 صفحه PDF سفارش دهید 5258 کلمه
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Escherichia coli O157:H7 virulence factors differentially impact cattle and bison macrophage killing capacity
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Microbial Pathogenesis, Volume 118, May 2018, Pages 251-256

پیش نمایش مقاله
پیش نمایش مقاله

چکیده انگلیسی

Enterohemorrhagic Escherichia coli O157:H7 colonizes the gastrointestinal tract of ruminants, including cattle and bison, which are reservoirs of these zoonotic disease-causing bacteria. Healthy animals colonized by E. coli O157:H7 do not experience clinical symptoms of the disease induced by E. coli O157:H7 infections in humans; however, a variety of host immunological factors may play a role in the amount and frequency of fecal shedding of E. coli O157:H7 by ruminant reservoirs. How gastrointestinal colonization by E. coli O157:H7 impacts these host animal immunological factors is unknown. Here, various isogenic mutant strains of a foodborne isolate of E. coli O157:H7 were used to evaluate bacterial killing capacity of macrophages of cattle and bison, the two ruminant species. Cattle macrophages demonstrated an enhanced ability to phagocytose and kill E. coli O157:H7 compared to bison macrophages, and killing ability was impacted by E. coli O157:H7 virulence gene expression. These findings suggest that the macrophage responses to E. coli O157:H7 might play a role in the variations observed in E. coli O157:H7 fecal shedding by ruminants in nature.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.