دانلود مقاله ISI انگلیسی شماره 103948
کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
103948 2018 9 صفحه PDF سفارش دهید 7520 کلمه
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عنوان انگلیسی
Inactivation of the Ventrolateral Orbitofrontal Cortex Impairs Flexible Use of Safety Signals
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuroscience, Volume 379, 21 May 2018, Pages 350-358

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چکیده انگلیسی

Survival depends on adaptation to shifting environmental risks and opportunities. Regarding risks, the mechanisms which permit acquisition, recall, and flexible use of aversive associations is poorly understood. Drawing on the evidence that the orbital frontal cortex is critical to integrating outcome expectancies with flexible appetitive behavioral responses, we hypothesized that OFC would contribute to behavioral flexibility within an aversive learning domain. We introduce a fear conditioning procedure in which adult male rats were presented with shock-paired conditioned stimulus (CS+) or a safety cue (CS−). In a recall test, rats exhibit greater freezing to the CS+ than the CS−. Temporary inactivation of the ventrolateral OFC with muscimol prior to conditioning did not affect later discrimination, but inactivation after learning and prior to recall impaired discrimination between safety and danger cues. This result complements prior research in the appetitive domain and suggests that the OFC plays a general role in behavioral flexibility regardless of the valence of the CS.

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