دانلود مقاله ISI انگلیسی شماره 116290
کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
116290 2018 9 صفحه PDF سفارش دهید 6447 کلمه
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عنوان انگلیسی
A Mathematical Model and Experimental Verification of Optimal Nozzle Diameter in Needle-Free Injection
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Pharmaceutical Sciences, Volume 107, Issue 4, April 2018, Pages 1086-1094

پیش نمایش مقاله
پیش نمایش مقاله

چکیده انگلیسی

Needle-free injection (NFI), as an alternative drug delivery strategy, owns great potential. It is able to reduce complaints about needle phobia and avoid the occurring of accidental needle stick injuries. The nozzle diameter is inherently important in determining the injection dose, injection depth, and pain associated with NFIs. In this work, needle-free injectors with nozzle diameters of 0.17, 0.20, 0.30, 0.40, and 0.50 mm were studied in the simulation and experiment. This article optimizes the mathematical model for spring-powered NFI by considering the hydraulic loss due to the abrupt change in the nozzle exit area and the friction force between the piston and ampoule. We explore the dispersion pattern in gels with different nozzle diameters. Mice insulin injection was conducted to investigate the pharmacological effect of different injection methods. The experimental results show that there is the best dispersion effect and available injection depth while the nozzle diameter is 0.30 mm, which is in agreement with the result predicted by the mathematical model. Also, there is a satisfactory pharmacological effect on the mice insulin injection under the same injection condition. Undoubtedly, the mathematical model is capable of predicting the suitable nozzle diameter under the given conditions.

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