دانلود مقاله ISI انگلیسی شماره 120503
کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
120503 2017 25 صفحه PDF سفارش دهید 9497 کلمه
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Childhood maltreatment is associated with alteration in global network fiber-tract architecture independent of history of depression and anxiety
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : NeuroImage, Volume 150, 15 April 2017, Pages 50-59

پیش نمایش مقاله
پیش نمایش مقاله

چکیده انگلیسی

Childhood maltreatment is a major risk factor for psychopathology. It is also associated with alterations in the network architecture of the brain, which we hypothesized may play a significant role in the development of psychopathology. In this study, we analyzed the global network architecture of physically healthy unmedicated 18–25 year old subjects (n=262) using diffusion tensor imaging (DTI) MRI and tractography. Anatomical networks were constructed from fiber streams interconnecting 90 cortical or subcortical regions for subjects with no-to-low (n=122) versus moderate-to-high (n=140) exposure to maltreatment. Graph theory analysis revealed lower degree, strength, global efficiency, and maximum Laplacian spectra, higher pathlength, small-worldness and Laplacian skewness, and less deviation from artificial networks in subjects with moderate-to-high exposure to maltreatment. On balance, local clustering was similar in both groups, but the different clusters were more strongly interconnected in the no-to-low exposure group. History of major depression, anxiety and attention deficit hyperactivity disorder did not have a significant impact on global network measures over and above the effect of maltreatment. Maltreatment is an important factor that needs to be taken into account in studies examining the relationship between network differences and psychopathology.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.