دانلود مقاله ISI انگلیسی شماره 121982
کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
121982 2018 9 صفحه PDF سفارش دهید 7917 کلمه
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عنوان انگلیسی
Propranolol disrupts consolidation of emotional memory in Lymnaea
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 149, March 2018, Pages 1-9

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چکیده انگلیسی

The therapeutic efficacy of the synthetic β-adrenergic receptor blocker, propranolol, for the treatment of post-traumatic stress disorder (PTSD) is currently being debated. Mixed results have been published regarding propranolol’s ability to disrupt the consolidation and reconsolidation of memories. Here, we use the invertebrate model Lymnaea to study propranolol’s ability to disrupt consolidation of memories formed under varying various types of stress which cause differing degrees of emotional memory. We show that when propranolol is administered immediately following operant conditioning, only the consolidation process of memories enhanced by individual stressors (i.e. a non-emotional memory) is susceptible to disruption. However, when propranolol is administered prior to training, only memories enhanced by a combination of stressors leading to an emotional memory are susceptible to disruption. These data suggest that the time of propranolol administration, as well as the type of memory formed play a key role in propranolol’s ability to obstruct memory consolidation.

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