دانلود مقاله ISI انگلیسی شماره 122027
کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
122027 2017 23 صفحه PDF سفارش دهید 5675 کلمه
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عنوان انگلیسی
Corticosterone administration after a single-trial contextual fear conditioning does not influence the strength and specificity of recent and remote memory in rats
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Physiology & Behavior, Volume 171, 15 March 2017, Pages 175-180

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چکیده انگلیسی

It is well established that corticosterone (CORT) enhances memory consolidation of emotionally arousing experiences. Despite emotional memories being usually referred to as well remembered for long periods, there are no studies that have investigated the effects of CORT in modulating the duration and specificity of memory. In the present study, we trained Wistar rats in a single-trial contextual fear conditioning protocol and injected CORT (0.3, 1.0 or 3.0 mg/kg), immediately after training, to investigate its effects on memory consolidation. Rats were tested 2 and 29 days after the training session or only 29 days after training to assess recent or remote memory. Our results show that animals tested for recent memory discriminated the training context from a novel one, while those tested only for remote memory generalized the fear response to both contexts. Animals tested for remote memory after being tested for recent memory were able to discriminate both contexts. These results support the literature regarding memory specificity and duration. However, CORT treatment, even at the dose of 1.0 mg/kg that effectively enhanced the plasmatic hormone levels, did not affect the strength or the specificity of memory in either recent or remote memory tests. We hypothesize that the lack of effect of CORT treatment could be due to the low arousing training experience of the single-trial protocol which, despite being sufficient to induce significant recent and remote memory consolidation, may not be sufficient to allow the memory-enhancing effect of CORT.

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