دانلود مقاله ISI انگلیسی شماره 122040
ترجمه فارسی عنوان مقاله

آیا حافظه مقاوم در برابر انقراض می تواند باعث آسیب در سازگاری در راه رفتن شود؟ یک مطالعه تجربی با استفاده از موش بالغ

عنوان انگلیسی
Can an aversive, extinction-resistant memory trigger impairments in walking adaptability? An experimental study using adult rats
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
122040 2018 15 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuroscience Letters, Volume 665, 5 February 2018, Pages 224-228

ترجمه کلمات کلیدی
حافظه مخرب، فشار، سازگاری قدم زدن، پیاده روی ماهر،
کلمات کلیدی انگلیسی
Aversive memory; Stress; Walking adaptability; Skilled walking;
پیش نمایش مقاله
پیش نمایش مقاله  آیا حافظه مقاوم در برابر انقراض می تواند باعث آسیب در سازگاری در راه رفتن شود؟ یک مطالعه تجربی با استفاده از موش بالغ

چکیده انگلیسی

Cognitive demands can influence the adaptation of walking, a crucial skill to maintain body stability and prevent falls. Whilst previous research has shown emotional load tunes goal-directed movements, little attention has been given to this finding. This study sought to assess the effects of suffering an extinction-resistant memory on skilled walking performance in adult rats, as an indicator of walking adaptability. Thus, 36 Wistar rats were divided in a two-part experiment. In the first part (n = 16), the aversive, extinction-resistance memory paradigm was established using a fear-conditioning chamber. In the second, rats (n = 20) were assessed in a neutral room using the ladder rung walking test before and tree days after inducing an extinction-resistance memory. In addition, the elevated plus-maze test was used to control the influence of the anxiety-like status on gait adaptability. Our results revealed the shock group exhibited worse walking adaptability (lower skilled walking score), when compared to the sham group. Moreover, the immobility time in the ladder rung walking test was similar to the controls, suggesting that gait adaptability performance was not a consequence of the fear generalization. No anxiety-like behavior was observed in the plus maze test. Finally, correlation coefficients also showed the skilled walking performance score was positively correlated with the number of gait cycles and trial time in the ladder rung walking test and the total crossings in the plus maze. Overall, these preliminary findings provide evidence to hypothesize an aversive, extinction-resistant experience might change the emotional load, affecting the ability to adapt walking.