|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|140547||2018||7 صفحه PDF||سفارش دهید||4962 کلمه|
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Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Biosensors and Bioelectronics, Volume 106, 30 May 2018, Pages 86-92
In this study, we developed and validated a single-shank silicon-based neural probe with 128 closely-packed microelectrodes suitable for high-resolution extracellular recordings. The 8-mm-long, 100-Âµm-wide and 50-Âµm-thick implantable shank of the probe fabricated using a 0.13-Âµm complementary metal-oxide-semiconductor (CMOS) metallization technology contains square-shaped (20 Ã 20â¯Âµm2), low-impedance (~ 50â¯kÎ© at 1â¯kHz) recording sites made of rough and porous titanium nitride which are arranged in a 32 Ã 4 dense array with an inter-electrode pitch of 22.5â¯Âµm. The electrophysiological performance of the probe was tested in in vivo experiments by implanting it acutely into neocortical areas of anesthetized animals (rats, mice and cats). We recorded local field potentials, single- and multi-unit activity with superior quality from all layers of the neocortex of the three animal models, even after reusing the probe in multiple (> 10) experiments. The low-impedance electrodes monitored spiking activity with high signal-to-noise ratio; the peak-to-peak amplitude of extracellularly recorded action potentials of well-separable neurons ranged from 0.1â¯mV up to 1.1â¯mV. The high spatial sampling of neuronal activity made it possible to detect action potentials of the same neuron on multiple, adjacent recording sites, allowing a more reliable single unit isolation and the investigation of the spatiotemporal dynamics of extracellular action potential waveforms in greater detail. Moreover, the probe was developed with the specific goal to use it as a tool for the validation of electrophysiological data recorded with high-channel-count, high-density neural probes comprising integrated CMOS circuitry.