دانلود مقاله ISI انگلیسی شماره 157129
کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
157129 2018 37 صفحه PDF سفارش دهید 8866 کلمه
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عنوان انگلیسی
Mechanism and Structural Factors of Lipid and Surfactant in the Formation of Self-emulsified Nanoemulsion
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Pharmaceutical Sciences, Available online 4 April 2018

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چکیده انگلیسی

The study aims to elucidate the mechanism and the role of the molecular structure of surfactants and lipids in the formation of an oil-in-water (o/w) self-emulsified nanoemulsions (SEN). Hypothesis: The overall change of Gibb’s free energy (ΔGf) during the mixing of the lipid and surfactant, the formation of the interface between the lipid nano-droplets and water, and the dispersion of the lipid nano-droplets into the water, are the determinants of the formation of SEN, which are the result of the intermolecular interactions between the excipients involved. Various lipids and surfactants of different structures were studied for the possible formation of SEN. The results demonstrate that the formation of SEN requires 1) enough hydrophobic attractions between the surfactant molecule and the lipid molecule, which can break up the lipid-lipid and surfactant-surfactant intermolecular binding forces; and 2) the surfactant to be able to associate with enough water molecules which can effectively cover the lipid droplets’ surface to prevent coalescence.

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