|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|157129||2018||37 صفحه PDF||سفارش دهید||8866 کلمه|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Journal of Pharmaceutical Sciences, Available online 4 April 2018
The study aims to elucidate the mechanism and the role of the molecular structure of surfactants and lipids in the formation of an oil-in-water (o/w) self-emulsified nanoemulsions (SEN). Hypothesis: The overall change of Gibbâs free energy (ÎGf) during the mixing of the lipid and surfactant, the formation of the interface between the lipid nano-droplets and water, and the dispersion of the lipid nano-droplets into the water, are the determinants of the formation of SEN, which are the result of the intermolecular interactions between the excipients involved. Various lipids and surfactants of different structures were studied for the possible formation of SEN. The results demonstrate that the formation of SEN requires 1) enough hydrophobic attractions between the surfactant molecule and the lipid molecule, which can break up the lipid-lipid and surfactant-surfactant intermolecular binding forces; and 2) the surfactant to be able to associate with enough water molecules which can effectively cover the lipid dropletsâ surface to prevent coalescence.