دانلود مقاله ISI انگلیسی شماره 30241
عنوان فارسی مقاله

تغییر وضعیت استراحت جریان خون مغزی و اتصال آن در اسکیزوفرنی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
30241 2015 8 صفحه PDF سفارش دهید 5330 کلمه
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Altered resting-state cerebral blood flow and its connectivity in schizophrenia
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 63, April 2015, Pages 28–35

کلمات کلیدی
- برچسب چرخش شریانی - جریان خون مغزی - اتصال - تصویربرداری رزونانس مغناطیسی - اسکیزوفرنیا -
پیش نمایش مقاله
پیش نمایش مقاله تغییر وضعیت استراحت جریان خون مغزی و اتصال آن در اسکیزوفرنی

چکیده انگلیسی

Small sample sizes and large inter-subject variations result in inconsistent findings in resting-state cerebral blood flow (CBF) in schizophrenia. The CBF connectivity alterations in schizophrenia remain unclear. Recently, three-dimensional pseudo-continuous arterial spin labeling (pcASL) imaging was performed to measure the resting-state CBF in 100 schizophrenia patients and 94 healthy comparison subjects. The normalized CBF was used to reduce the inter-subject variations. Both group comparisons in the CBF and correlations between the CBF alterations and clinical parameters were assessed. The CBF connectivity of the brain regions with regional CBF differences was also compared between the groups. Compared with the healthy controls, the schizophrenia patients exhibited increased CBF in the bilateral inferior temporal gyri, thalami and putamen and decreased CBF in the left insula and middle frontal gyrus and the bilateral anterior cingulate cortices and middle occipital gyri. In the schizophrenia patients, significant correlations were identified between the CBF and clinical parameters. Importantly, the schizophrenia patients exhibited CBF disconnections between the left thalamus and right medial superior frontal gyrus and between the left insula and left postcentral gyrus. Our results suggest that schizophrenia patients may exhibit both regional CBF abnormalities and deficits in CBF connectivity, which may underlie the clinical symptoms of schizophrenia.

مقدمه انگلیسی

Schizophrenia is a common and severe brain disorder characterized by abnormal mental activities and disturbed behaviors (Lewis and Lieberman, 2000). It has been associated with alterations in resting-state cerebral blood flow (CBF). Positron emission tomography (PET) and single photon emission computerized tomography (SPECT) have traditionally been used to measure CBF changes in schizophrenia. Patients have exhibited increased or decreased resting-state CBF in multiple brain regions, especially the prefrontal cortex (Andreasen et al., 1997, Catafau et al., 1994, Kanahara et al., 2013, Kanahara et al., 2009, Kawasaki et al., 1993, Malaspina et al., 2004, Mathew et al., 1988, Rubin et al., 1994 and Weinberger et al., 1986). Moreover, several resting-state CBF alterations have been associated with the core clinical symptoms of schizophrenia (Lahti et al., 2006 and Yuasa et al., 1995). However, PET and SPECT techniques require the use of invasive radioactive tracers, which limits repeated examinations. The other limitations of the two techniques include the time-consuming, expensive image acquisition and low spatial resolution. With the advantages of a noninvasive nature and short acquisition time, arterial spin labeling (ASL) magnetic resonance imaging (MRI) provides an alternative approach to the measurement of resting-state CBF using magnetically labeled arterial blood water as an endogenous tracer (Detre et al., 1992). Using this technique, several studies have demonstrated resting-state CBF changes in schizophrenia (Liu et al., 2012, Pinkham et al., 2011, Scheef et al., 2010 and Walther et al., 2011), although one study failed to identify significant group differences (Horn et al., 2009). Furthermore, associations between the altered resting-state ASL-CBF and clinical symptoms have also been identified in schizophrenia (Pinkham et al., 2011). Although the decreased CBF in the frontal cortex has been repeatedly discerned in schizophrenia, the CBF changes in other brain regions differ largely across studies (Liu et al., 2012, Pinkham et al., 2011, Scheef et al., 2010 and Walther et al., 2011). The small sample size and large inter-subject variations may account for the inconsistent findings across investigations. Thus, studies that investigate normalized CBF to reduce inter-subject variations in a larger sample size are needed. As a reflection of neuronal activity, the regional CBFs of different brain regions are not independent. Instead, the CBFs of brain regions from the same functional network may change synchronously to fulfill the function of the network. In support of the hypothesis, the highest concurrent fluctuations in CBF have been identified between homologous cortical regions, and the functional network constructed by CBF connectivity exhibits similar network properties to the networks constructed by anatomical or functional connectivity (Melie-Garcia et al., 2013). Recently, using a group-level independent component analysis on ASL-CBF data, Kindler and colleagues have found increased CBF connectivity within the default-mode network (DMN) (Kindler et al., 2015). However, the CBF connectivity alterations outside the DMN in schizophrenia remain largely unknown. The first aim of this current study was to clarify the CBF alteration patterns in schizophrenia. We adopted a 3D pseudo-continuous arterial spin labeling (pcASL) technique that used fast spin echo acquisition and background suppression to provide robustness to motion and susceptibility artifacts and to improve the signal to noise ratio (SNR). We used normalized CBF to reduce the inter-subject difference and a large sample size (100 patients with schizophrenia and 94 healthy comparison subjects) to improve the statistical power. To exclude the effect of cortical atrophy on the CBF results, we also repeated the CBF comparisons after controlling for the regional gray matter volume (GMV). The second aim was to investigate the associations between CBF alterations and clinical parameters. The final aim was to test whether the brain regions with altered CBF also exhibited CBF connectivity changes in schizophrenia.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.