دانلود مقاله ISI انگلیسی شماره 30340
عنوان فارسی مقاله

بهینه سازی یک مدل چندگانه برای بررسی توهم و هذیان های با مانیتورینگ مبدأ

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
30340 2006 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
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عنوان انگلیسی
Optimization of a multinomial model for investigating hallucinations and delusions with source monitoring
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Schizophrenia Research, Volume 85, Issues 1–3, July 2006, Pages 106–112

کلمات کلیدی
- اسکیزوفرنی - نظارت بر منب - مدل سازی چندگانه - توهم - هذیان -
پیش نمایش مقاله
پیش نمایش مقاله بهینه سازی یک مدل چندگانه برای بررسی توهم و هذیان های با مانیتورینگ مبدأ

چکیده انگلیسی

Studies of source monitoring have played an important role in cognitive investigations of the inner/outer confusions that characterize hallucinations and delusions in schizophrenia, and multinomial modelling is a statistical/cognitive modelling technique that provides a powerful method for analyzing source monitoring data. The purpose of the current work is to describe how multinomial models can be optimized to answer direct questions about hallucinations and delusions in schizophrenia research. To demonstrate this, we present a reanalysis of previously published source monitoring data, comparing a group of patients with schneiderian first rank symptoms to a group without schneiderian first rank symptoms. The main findings of this analysis were (1) impaired recognition of self-generated items and (2) evidence that impaired source discrimination of perceived items is accompanied by an internalization bias in the target symptom group. Statistical and cognitive interpretations of the findings are discussed.

مقدمه انگلیسی

Fundamental to an understanding of reality distortion in schizophrenia (i.e., hallucinations and delusions) is the study of inner/outer confusions in cognition (Fowler, 2000). This relationship is most apparent when considering auditory hallucinations, as these can be conceptualized as the assignment of internally generated mental events to an external source. Originally referred to as reality monitoring (Johnson et al., 1993), the study of inner/outer confusions in memory has recently been employed to investigate the cognitive underpinnings of schizophrenia, typically under the rubric of source monitoring (e.g., Brébion et al., 2000, Keefe et al., 2002, Moritz et al., 2003, Moritz et al., 2005, Morrison and Haddock, 1997 and Vinogradov et al., 1997). One of the limitations of many of these studies is that guessing strategies (e.g., strategically increasing external-source guesses) have not been separated from memory errors; however, multinomial modelling allows these processes to be separately measured. Multinomial models attempt to explain discrete responses in a particular psychological paradigm by postulating latent cognitive processes that combine in different ways to determine the response category. The basic idea is that any given response category may occur as a consequence of one or more processing sequences, where each processing sequence is characterized by a series of successful or unsuccessful processing events. The processing sequences are represented in a tree structure (see Fig. 1). The root (or initial node) represents the beginning of the processing sequence, the intermediate nodes represent stages involving a choice between two or more processing events, and the terminal nodes correspond to the observable response categories. The application of multinomial models to source monitoring has been reviewed in detail elsewhere (Batchelder and Riefer, 1999). Full-size image (37 K) Fig. 1. Tree diagrams for the final three-source multinomial model, with separate trees for self-generated, picture, heard source items, and new items. D1 = probability of recognizing self-generated items as old; D2 = probability of recognizing picture items as old; D3 = probability of recognizing heard items as old; d1 = probability of discriminating the source of recognized self-generated items; d2 = probability of discriminating the source of recognized picture items; d3 = probability of discriminating the source of recognized heard items; a1 = probability of externalization when self-generated items are recognized but not discriminated; a2 = probability of internalization when picture items are recognized but not discriminated; a3 = probability of internalization when heard items are recognized but not discriminated; e1 = probability of attributing a self-generated item to the heard source if an externalization is made; e2 = probability of confusing the two external sources for picture items; e3 = probability of confusing the two external sources for heard items. Figure options Multinomial modelling provides separate source misattribution parameters for when items are recognized and when items are not recognized; we refer to the former as biases, and the latter as guesses. It is the biases, which affect reactivated “in mind” cognitive representations (i.e., recognized items in the source monitoring memory context), that are of primary interest for the study of hallucinations and delusions ( Keefe et al., 2002, p. 53). Multinomial models used in previous studies of schizophrenia ( Keefe et al., 2002 and Keefe et al., 1999) were developed within the context of cognitive psychology, but were not optimized for the study of hallucinations and delusions. In traditional multinomial models, parameters are created for old and new recognition (parameter D in Fig. 1), source recognition (parameter d in Fig. 1) and biases. However, estimates of true internalization and externalization biases are not possible, because parameter estimates do not vary with the originating source. That is to say, unlike the recognition (parameters D1–3, see Fig. 1) and source discrimination (parameters d1–3, see Fig. 1) estimates, biases affecting recognized but not discriminated items were equated for items with internal and external origins (referred to as as, ap and ah in Keefe et al., 2002, Fig. 3). 1 To understand the importance of this distinction, consider that the externalizing account of hallucinations applies specifically to internally generated cognitive operations. Therefore, to properly test the externalization account of hallucinations, a bias towards the external source must be specific to items originating from the internal source, and must not generalize to other items. Multinomial modelling is flexible with respect to the models that can be tested, and externalization and internalization biases for recognized items can be measured for external and internal sources separately, such that an appropriate test for the cognitive underpinnings of reality distortion can be achieved. In order to directly compare the models developed within the tradition of cognitive psychology with those optimized for schizophrenia research, we reanalyzed previously published data (Keefe et al., 2002). These data are derived from a three-source source monitoring experiment, for which 16 words are presented from each of three sources: self (word stem completed by subject), picture (pictures presented on a card) and heard (words read aloud by the experimenter). In a recognition trial, these 42 previously presented words, along with 16 new words, were presented on a test sheet, and subjects were asked to make new/old and source judgements at their own pace. Two groups of patients split on the presence of schneiderian first rank symptoms were compared; the originally published patient–control comparison was not carried out using the model introduced here (explained in more detail below). Sample sizes are presented in Table 1, but for all other aspects of sample description and methodology, please refer to the Methods section of the original article (Keefe et al., 2002). Table 1. Response frequencies for target vs. non-target schizophrenia patients as a function of source and response (from Keefe et al., 2002) Source Response Self-generated Picture Heard New Target symptom group (N = 18) Self-generated 323 (56) 55 (10) 95 (16) 103 (18) Picture 21 (4) 502 (87) 19 (3) 34 (6) Heard 57 (10) 35 (6) 239 (41) 245 (43) New 32 (6) 25 (4) 90 (16) 429 (74) Non-target symptom group (N = 11) Self-generated 234 (66) 30 (9) 42 (12) 46 (13) Picture 3 (1) 322 (91) 6 (2) 21 (6) Heard 17 (5) 22 (6) 164 (47) 149 (42) New 18 (5) 16 (5) 52 (15) 266 (76) Row percentages are presented in parentheses. Correct responses are set in bold font.

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