دانلود مقاله ISI انگلیسی شماره 30763
عنوان فارسی مقاله

پتانسیل MRI عملکردی به عنوان نشانگر در اوایل بیماری آلزایمر

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
30763 2011 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
The potential of functional MRI as a biomarker in early Alzheimer's disease
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 32, Supplement 1, December 2011, Pages S37–S43

کلمات کلیدی
'بیماری آلزایمر - نشانگر - اختلال شناختی - زوال عقل -
پیش نمایش مقاله
پیش نمایش مقاله پتانسیل MRI عملکردی به عنوان نشانگر در اوایل بیماری آلزایمر

چکیده انگلیسی

Functional magnetic resonance imaging (fMRI) is a relative newcomer in the field of biomarkers for Alzheimer's disease (AD). fMRI has several potential advantages, particularly for clinical trials, as it is a noninvasive imaging technique that does not require the injection of contrast agent or radiation exposure and thus can be repeated many times during a longitudinal study. fMRI has relatively high spatial and reasonable temporal resolution, and can be acquired in the same session as structural magnetic resonance imaging. Perhaps most importantly, fMRI may provide useful information about the functional integrity of brain networks supporting memory and other cognitive domains, including the neural correlates of specific behavioral events, such as successful versus failed memory formation.

مقدمه انگلیسی

Functional magnetic resonance imaging (fMRI) is a relative newcomer in the field of biomarkers for Alzheimer's disease (AD). fMRI has several potential advantages, particularly for clinical trials, as it is a noninvasive imaging technique that does not require the injection of contrast agent or radiation exposure and thus can be repeated many times during a longitudinal study (Atri et al., 2011). fMRI has relatively high spatial and reasonable temporal resolution, and can be acquired in the same session as structural magnetic resonance imaging (MRI). Perhaps most importantly, fMRI may provide useful information about the functional integrity of brain networks supporting memory and other cognitive domains, including the neural correlates of specific behavioral events, such as successful versus failed memory formation (Brewer et al., 1998, Miller et al., 2008a, Sperling et al., 2003b and Wagner et al., 1998). However, there are very limited published data on fMRI test-retest or cross-scanner platform reproducibility, or correlation with longitudinal clinical outcome, and the majority of fMRI studies performed to date have enrolled small, highly selected cohorts within single academic centers.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.