دانلود مقاله ISI انگلیسی شماره 31899
عنوان فارسی مقاله

اثرات آموزش آرام سازی بر پارامترهای روان سنجی و ایمونولوژیک در افراد مبتلا به وزوز گوش

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
31899 2002 15 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Impact of a relaxation training on psychometric and immunologic parameters in tinnitus sufferers
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychosomatic Research, Volume 52, Issue 1, January 2002, Pages 29–33

کلمات کلیدی
سایتوکاین - آموزش آرام سازی - استرس - وزوز گوش - تومور آلفا فاکتور نکروز -
پیش نمایش مقاله
پیش نمایش مقاله اثرات آموزش آرام سازی بر پارامترهای روان سنجی و ایمونولوژیک در افراد مبتلا به وزوز گوش

چکیده انگلیسی

Objective: Tinnitus often entails severe psychological distress. Reversely, tinnitus may be considered as a chronic stressor. Based on this hypothesis, we investigated whether improving stress-managing capabilities would influence psychological and stress-related immunological parameters in chronic tinnitus sufferers. Methods: Tinnitus (TPs, n=26) and non-tinnitus participants (NTPs, n=13) took part in a standardised 10-week relaxation program. An additional group of tinnitus sufferers (n=18), randomly assigned to a waiting list, served as control (TC) subjects. Mood, perceived stress, global quality of life, and tinnitus disturbance were assessed before and after the intervention. The stress-sensitive immunological parameters TNF-α, IL-6, and IL-10 were measured before, during, and at the end of the intervention. Results: The program resulted in a significantly decreased perception of stress, anxious depression, anger, and tinnitus disturbance, paralleled by a reduction of TNF-α. No alterations were noted for IL-6 or IL-10. For the NTPs and TCs, no relevant psychological or immune changes could be observed. Conclusion: The data suggest that (1) the training offered improved stress-managing capabilities in chronic tinnitus sufferers, and (2) TNF-α may be conceived as a stress marker.

مقدمه انگلیسی

A link between tinnitus and psychological distress has been confirmed in many studies [1], [2], [3], [4], [5] and [6]. Given the association between tinnitus and psychological distress, tinnitus may also be regarded as a chronic stressor, creating a vicious circle of stress and an exacerbation of tinnitus [7]. Psychoneuroimmunological research has given substantial evidence for the fact that psychological distress is associated with dramatic changes in immune measures [8], [9] and [10]. Uncontrollability of the stressor has been identified as a major determinant of the immunological stress response [11] and [12], a characteristic that also applies to the condition of tinnitus. We therefore hypothesised that tinnitus, perceived as disturbing and uncontrollable, acts like a chronic stressor and thereby interferes with stress-related Th1/Th2 cytokines. TNF-α was selected as a marker of the Th1 cytokines, since it has been shown to react to acute stress in mice models [13] as well as to psychological stress in humans [14] and [15]. IL-6 and IL-10 represent Th2 cytokines. Increased IL-6 levels have been described in association with psychological stress and major depressive disorders [16] and [17]. IL-10 has also been demonstrated to increase with psychological stress [15], although stress-related alterations of this cytokine are still not fully elucidated.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.