دانلود مقاله ISI انگلیسی شماره 32482
عنوان فارسی مقاله

خود تخریب و عملکرد سروتونین در بولیمیا

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
32482 2001 12 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Self-destructiveness and serotonin function in bulimia nervosa
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 103, Issue 1, 5 August 2001, Pages 15–26

کلمات کلیدی
- خودکشی - خود زنی - اختلالات اشتها - کورتیزول - پرولاکتین -
پیش نمایش مقاله
پیش نمایش مقاله خود تخریب و عملکرد سروتونین در بولیمیا

چکیده انگلیسی

Studies have linked bulimia nervosa (BN) to alterations in brain serotonin (5-hydroxytryptamine: 5-HT) activity and to heightened propensity for parasuicidality and self-injuriousness. The coincidence of self-destructiveness and 5-HT abnormality in BN is of interest, given documentation (in various populations) of an inverse association between 5-HT activity and potential for self-harm. The present study examined the connection between 5-HT status and self-destructiveness in BN. Structured interviews and self-report questionnaires were used to assess 40 bulimic and 21 normal-eater women for: (a) history of parasuicidal or self-injurious acts; and (b) mood and impulse-regulation problems. We then applied tests, presumed to reflect 5-HT function, of serial prolactin (PRL) and cortisol (CORT) responses after oral administration of the partial 5-HT agonist, meta-chlorophenylpiperazine (m-CPP). Relative to non-bulimic women, bulimic women (on average) showed blunting of PRL and CORT following m-CPP. The blunting of neuroendocrine responses was, however, most remarkable in bulimic women with a history of self-destructiveness. These findings suggest that some serotonergic anomalies reported in BN sufferers (i.e. reduced neuroendocrine response after m-CPP) may be most characteristic of individuals in the population showing clear-cut self-destructive potential.

مقدمه انگلیسی

Evidence suggests that bulimia nervosa (BN) coincides with alterations in central serotonin (5-hydroxytryptamine: 5-HT) activity (Brewerton, 1995 and Wolfe et al., 1997). Studies in bulimic patients have documented decreased 5-HT metabolites in cerebrospinal fluid (CSF: Jimerson et al., 1992), reduced platelet binding of the 5-HT uptake inhibitors [3H]imipramine (Marazziti et al., 1988) and [3H]paroxetine (Steiger et al., 2000) and blunted prolactin (PRL) responses to 5-HT agonists or partial agonists (Brewerton et al., 1992 and Levitan et al., 1997). Data from independent studies show bulimic patients to display prominent parasuicidality or self-mutilation behaviours (Mitchell et al., 1986) and some findings (most based on very small samples) suggest that impulsive symptoms in BN may correspond to greater abnormality on various indices of 5-HT functioning (Steiger et al., 2001, Verkes et al., 1996 and Waller et al., 1996). Coincidence of self-destructiveness and 5-HT abnormality in BN is intriguing, given documentation in other psychiatric populations of a systematic (inverse) association between 5-HT activity and self-destructive (i.e. parasuicidal or self-injurious) potentials. For example, research in depressed and personality-disordered patients has linked suicidal, self-injurious and/or impulsive–aggressive behaviors to: (a) low CSF 5-hydroxyindoleacetic acid (5-HIAA: Åsberg et al., 1987 and Lopez-Ibor et al., 1985); (b) decreased 5-HT and imipramine binding in post-mortem brain tissue (Stanley et al., 1982); (c) reduced PRL responses following the 5-HT agonist d,l-fenfluramine (Coccaro et al., 1989 and New et al., 1997); and (d) blunted metabolic responses, measured by positron emission tomography, following administration of the 5-HT agonist d,l-fenfluramine (Siever et al., 1999 and Soloff et al., 2000). Such findings motivated us to explore the association between serotonin status and self-harming behaviors in BN. In the present study, we assessed 5-HT function by measuring PRL and cortisol (CORT) responses following oral administration of the partial 5-HT agonist, meta-chlorophenylpiperazine (m-CPP). The rationale for this procedure rests upon the assumption that stimulation with 5-HT agents results in increased release of PRL (via serotonergic pathways into the pituitary) and CORT (via indirect hypothalamic–pituitary–adrenal axis connections). As it binds with highest affinity to 5-HT2c receptors and lesser affinity to 5-HT1a and alpha2-noradrenergic receptors, m-CPP is thought to constitute a fairly specific probe of postsynaptic 5-HT function (Yatham and Steiner, 1993). The PRL and CORT response following m-CPP administration has been used to study 5-HT neurotransmission in several previous studies on BN (Brewerton et al., 1992, Levitan et al., 1997 and Steiger et al., 2001).

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