سطح پیشرفته سرم کلسترول و تری گلیسرید در بولیمیا: روابط برای هم ابتلایی، آسیب شناسی روانی و متغیرهای هورمونی
|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|32499||2005||7 صفحه PDF||سفارش دهید||3801 کلمه|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Psychiatry Research, Volume 134, Issue 3, 30 April 2005, Pages 267–273
Increased levels of cholesterol have been reported in patients with bulimia nervosa (BN), but all but one of the published studies were performed on non-fasting subjects, which limits the interpretation of this finding. Moreover, the relationships between serum lipids and comorbid psychiatric disorders or bulimic psychopathology have scarcely been investigated. We measured serum levels of total cholesterol, triglycerides, glucose, 17β-estradiol and thyroid hormones in 75 bulimic women and 64 age-matched healthy females after an overnight fast. Compared with healthy women, bulimic patients exhibited significantly enhanced serum levels of cholesterol and triglycerides, but similar values of glucose, 17β-estradiol, FT3 and FT4. No significant differences emerged in these variables between patients with or without comorbid depression, borderline personality disorder or lifetime anorexia nervosa. Circulating cholesterol was positively correlated to the patients' drive for thinness, ineffectiveness, enteroceptive awareness and impulse regulation sub-item scores of the Eating Disorder Inventory-2. These findings confirm that BN is associated with increased levels of serum lipids. This alteration may be involved in the pathophysiology of certain psychopathological characteristics of BN and cannot be explained by the co-occurrence of other psychiatric disorders.
A wide range of peripheral biochemical abnormalities has been reported in patients with anorexia nervosa (AN) or bulimia nervosa (BN) (Brambilla and Monteleone, 2003). Although these alterations have been generally regarded as secondary to the chronic malnutrition that follows the abnormal eating behaviours of these patients, they may contribute to the maintenance of the disorders themselves and/or to the genesis of organic and psychopathological complications. Among the biochemical alterations detected in people with eating disorders (EDs), metabolic abnormalities, such as changes in glucose, lipid and protein homeostasis, are relatively common. In particular, lipid alterations are present in at least 50% of anorexics and are mainly represented by increased total serum cholesterol concentrations that do not correlate with thyroid dysfunction, severity of weight loss, dietary intake of nutrients, and presence of purging behaviours (Klinefelter, 1965, Nestel, 1974, Mordasini et al., 1979, Mira et al., 1985, Mira et al., 1987 and Sanchez-Muniz et al., 1991). In BN, hypercholesterolemia has also been reported, but not adequately investigated. Indeed, some studies include relatively small samples of subjects (Vize and Coker, 1994 and Case et al., 1999), some do not have a normal control group (Vize and Coker, 1994 and Sullivan et al., 1998), and others may cover overlapping subject sets (Mira et al., 1985 and Mira et al., 1987). Furthermore, five of the seven available studies measured cholesterol levels in non-fasting patients (Mira et al., 1985, Mira et al., 1987, Vize and Coker, 1994, Sullivan et al., 1998 and Pauporte and Walsh, 2001), one reported longitudinal variations in serum cholesterol and triglycerides in a sample of fasted patients who were initially tested in a non-fasting state (Gendall et al., 2002), and only one assessed fasting cholesterol concentrations in a very limited number of bulimics (only 10 patients) (Case et al., 1999). Therefore, it is possible that the hypercholesterolemia reported in BN is related to the non-fasting status of the studied subjects. The elucidation of this issue is of great relevance. In fact, because of the chronic nature of BN, a persistent hypercholesterolemia may have potentially negative consequences on the subjects' health, since it increases the risk of coronary heart disease or stroke (Archbold and Timmis, 1998). Moreover, in patients with psychiatric disorders other than EDs, changes in total serum cholesterol concentrations have been associated with certain psychopathological dimensions such as impulsivity, aggression, hostility, depression and suicidal tendencies (Apter et al., 1999, Almeida-Montes et al., 2000, Sarchiapone et al., 2001 and Agargun, 2002), which also frequently occur in people with BN. The relationships between serum cholesterol and psychopathology have been scarcely or not at all investigated in BN patients. Therefore, the possibility exists that changes in lipid concentrations are peculiar to those bulimics with comorbid Axis I/II psychiatric disorders and/or are related to specific psychopathological dimensions. In the present study, we measured morning levels of total serum cholesterol and triglycerides in a large sample of drug-free bulimic women and healthy women after 12-h fasting, and assessed the relationships between serum lipids and comorbid psychiatric disorders, psychopathology or hormonal variables.