دانلود مقاله ISI انگلیسی شماره 3353
عنوان فارسی مقاله

اثربخشی هزینه کلوپیدوگرل به اضافه آسپرین در مقابل اثربخشی هزینه آسپرین خالی برای پیشگیری ثانویه از حوادث قلبی عروقی : نتایج آزمون کاریزما

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
3353 2009 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Cost-Effectiveness of Clopidogrel plus Aspirin versus Aspirin Alone for Secondary Prevention of Cardiovascular Events: Results from the CHARISMA Trial
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Value in Health, Volume 12, Issue 6, September 2009, Pages 872–879

کلمات کلیدی
آسپرین - بیماری های قلبی عروقی - کلوپیدوگرل - تجزیه و تحلیل هزینه اثربخشی - پیشگیری ثانویه -
پیش نمایش مقاله
پیش نمایش مقاله اثربخشی هزینه کلوپیدوگرل به اضافه آسپرین در مقابل اثربخشی هزینه آسپرین خالی برای پیشگیری ثانویه از حوادث قلبی عروقی : نتایج آزمون کاریزما

چکیده انگلیسی

Objective To determine the incremental cost-effectiveness of clopidogrel plus aspirin (C + A) compared with aspirin (A) alone during the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial from a US payer perspective. Background Although the CHARISMA trial did not find a benefit of adding clopidogrel to aspirin in its overall study cohort, a benefit was suggested in a prespecified subgroup of patients with established cardiovascular (CV) disease. The cost-effectiveness of dual antiplatelet therapy in this population is unknown. Methods Medical resource utilization was assessed prospectively, and costs for hospitalizations, physician services, outpatient care, and medications were assigned using 2007 US dollars. Life expectancy was estimated contingent on fatal and nonfatal CV events using statistical models of long-term survival from the Saskatchewan Health database. Results C + A was associated with a 12.5% relative reduction in CV death, myocardial infarction, or stroke compared with A alone (6.9% vs. 7.9%, P = 0.048) over a median 28 months of follow-up. Severe or moderate bleeding events were higher in patients receiving C + A versus A alone (3.6% vs. 2.5%, P < 0.001). Mean cost/patient was $2607 higher for C + A, while projected life expectancy increased by an average of 0.072 years due to fewer in-trial events. The resulting incremental cost-effectiveness ratio (ICER) for C + A was $36,343/year of life gained. Findings were insensitive to discount rate, life expectancy projections, post-event costs, and indirect costs from lost productivity; the ICER was most sensitive to the cost of clopidogrel. Bootstrap analysis demonstrated that the ICER for C + A remained <$50,000/life-year gained in 70.6% of bootstrap replicates and <$100,000/life-year gained in 87.4%. Conclusions Among patients with established CV disease, adding clopidogrel to aspirin appears to increase life expectancy modestly at a cost generally considered acceptable within the US health-care system.

مقدمه انگلیسی

To determine the incremental cost-effectiveness of clopidogrel plus aspirin (C + A) compared with aspirin (A) alone during the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial from a US payer perspective.

نتیجه گیری انگلیسی

Among patients with established CV disease, adding clopidogrel to aspirin appears to increase life expectancy modestly at a cost generally considered acceptable within the US health-care system.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.