ارتباطات عصبی نارضایتی از بدن در بی اشتهایی عصبی
|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|33758||2010||8 صفحه PDF||سفارش دهید||محاسبه نشده|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Neuropsychologia, Volume 48, Issue 10, August 2010, Pages 2878–2885
Body dissatisfaction is an important precipitating and maintenance factor in anorexia nervosa (AN) and behavioral studies suggest that a cognitive–affective component and a perceptual component (perceptual disturbance of one's own body) are both important in this pathophysiology. However, the functional neuroanatomy of body dissatisfaction in AN is largely unknown. This study has investigated self-other body-shape comparison to establish neural correlates of body dissatisfaction in patients with AN. 17 women with AN and 18 age and sex-matched healthy control (HC) subjects were scanned using functional magnetic resonance imaging while comparing themselves with images of slim idealized female bodies (active condition) or viewing images of interior home designs (control condition). Participants were asked to compare their body shape or room design with those presented. Patients with AN (in comparison to the HC group) showed greater anxiety to the self-other body-shape comparison, and they were less satisfied with their current body shape. In the patient group (in comparison to the HC group) the self-other body-shape comparison induced more activation of the right sensorimotor brain regions (insula, premotor cortex) and less activation of the rostral anterior cingulate cortex (ACC). Insula hyperactivation along with ACC hypoactivation may be critical for altered interoceptive awareness to body self-comparison and/or for altered implicit motivation to thin-idealized body images in AN patients.
Body dissatisfaction is important in the development, maintenance and relapse of eating disorders (ED) including anorexia nervosa (AN) (Jacobi et al., 2004, Stice and Shaw, 2002, Taylor et al., 2006 and Windauer et al., 1993). Furthermore, “undue influence of weight and shape on self evaluation” is a diagnostic feature of AN (American Psychiatric Association, 1994). The body dissatisfaction present in people with AN is associated with a perceptual disturbance, an overestimation of body size (Cash & Deagle, 1997). Exposure to media images of female bodies and self-other comparison of body-shape elicits dissatisfaction with one's own body and emotional distress (i.e. anxiety) (Groesz, Levine, & Murnen, 2002). AN patients (despite their low body weight) report higher levels of anxiety when confronted with slim fashion models (Friederich et al., 2006) or line drawings of slim bodies (Uher et al., 2005). One mechanism that may contribute to heightened body dissatisfaction in people with AN is an overestimation of their body size (Cash & Deagle, 1997). As this problem is restricted to the estimation of their own body, there is an apparent inaccuracy in self-body representation and awareness and this is supported by recent data showing that they have an impaired perception of physiological feedback from their own body (Papezova et al., 2005, Pollatos et al., 2008 and Wagner et al., 2008). Functional neuroimaging studies have identified a neural network responsible for processing body-shape related information, comprised of the lateral occipitotemporal gyrus (including the extrastriate body area (EBA) and the fusiform body area (FBA)), the dorsolateral prefrontal cortex (PFC) and the parietal lobe, particularly within the right hemisphere (Friederich et al., 2007, Uher et al., 2005 and Wagner et al., 2003). Within this network, the occipito-parietal pathway is primarily involved in the detection of body related information and the parieto-frontal pathway represents body identification and self-other discrimination (Hodzic et al., 2009a and Hodzic et al., 2009b). Brain activations within the limbic network have been found in healthy controls exposed to distorted self-images (Kurosaki et al., 2006, Miyake et al., 2010 and Wagner et al., 2003), to self-other comparison of body shape (Friederich et al., 2007) and by using derogatory body-shape-related words (Shirao, Okamoto, Okada, Okamoto, & Yamawaki, 2003). These studies suggest an engagement of the limbic network including the prefrontal cortex, striatum and temporomesial structures including the amygdala that becomes activated in these conditions. Functional imaging studies in healthy individuals have identified the sensorimotor cortex including the mid-dorsal insula, the anterior insula and the anterior cingulate cortex as neural correlates for the representation of physiological feedback from the body and all subjective feelings from the body (Craig, 2003 and Pollatos et al., 2007). In patients with AN, several neuroimaging studies have investigated body image disturbance in response to body-shape images using whole brain analyses. In these, group differences with healthy controls were found primarily in the body-shape processing network (Beato-Fernandez et al., 2009, Uher et al., 2005 and Wagner et al., 2003). Additionally, during visual self-recognition (processing of self-images compared to non-self-images) and during exposure to distorted thin self-images, patients with AN showed altered insula activation (Mohr et al., in press and Sachdev et al., 2008). One study specifically assessed brain activation in the ventral striatal system and reported greater ventral striatal activity to underweight compared to normal weight body images in AN patients, whereas healthy controls showed a reversed pattern (Fladung et al., 2010). The authors suggest that increased metabolism in the reward system to underweight body images (i.e. starvation associated cues) support theories of starvation dependence in AN patients. However, it remains unclear whether body dissatisfaction in AN is associated with alterations in the ventral limbic network and/or in self-body representation and interoception. In the present study, we have enhanced the stimuli and the presentation protocol, on the basis of our previous experience with a body image paradigm (Uher et al., 2005) and induced self-schematic processing by giving instructions that encouraged participants to evaluate their own physical appearance in comparison to thin ideals. In contrast to paradigms of self-body recognition and self-body identification from externally presented self-images, the aim of the present paradigm was to induce interoceptive and emotional–motivational processing triggered by a self-other body-shape comparison. Using this paradigm we previously found that in healthy women, activations of the limbic system were associated with anxiety (Friederich et al., 2007). As patients with AN show higher anxiety in response to media images (Friederich et al., 2007), we hypothesized that (i) body-shape comparison is associated with greater activation of the ventral limbic system (i.e. ventral striatum, mesial temporal regions including the amygdala, rostral anterior cingulate cortex (ACC), ventral PFC) (Phillips, Drevets, Rauch, & Lane, 2003). Given the apparent inaccuracy in the estimation of one's own body size, we also hypothesized that (ii) areas involved in the processing of interoceptive awareness and self-body representation such as the insular cortex, sensorimotor cortical regions and the ACC would be differentially engaged in the patient compared to the control group (Craig, 2003 and Critchley et al., 2004).