کورتیکال کاهش یافته و حجم قشر فرعی در دختران نوجوان مبتلا به اختلال شخصیت مرزی
|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|34083||2014||8 صفحه PDF||سفارش دهید||6825 کلمه|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Psychiatry Research: Neuroimaging, Volume 221, Issue 3, 30 March 2014, Pages 179–186
Volumetric alterations in limbic structures have been detected in adults, but not in adolescents with borderline personality disorder (BPD). We examined adolescents in the early stages of BPD to provide a unique opportunity to investigate which parts of the brain are initially affected by the disorder before confounding factors such as long-term medication or chronicity can mask them. A group of 60 right-handed female adolescents between 14 and 18 years of age (20 patients with BPD, 20 clinical controls, and 20 healthy controls) underwent magnetic resonance imaging (MRI). Focus was on the examination of hippocampal and amygdalar volume differences. Furthermore, a cortical thickness analysis was conducted. FreeSurfer software detected significant group differences in the right and left hippocampus and in the right amygdala. Additionally, significant volume reductions in frontal (right middle frontal gyrus, orbital part of the inferior frontal gyrus bilaterally), and parietal regions (superior parietal gyrus bilaterally) were found in adolescents with BPD compared with controls. No group differences in cortical thickness were revealed.
Subjects who are affected by borderline personality disorder (BPD) suffer from mood instability and impulsiveness, show dysregulated behaviors such as non-suicidal self-injury, or have a history of multiple suicide attempts (Selby et al., 2009). They have difficulties in maintaining interpersonal relationships or trusting other people, and they may also experience cognitive symptoms such as paranoia or severe dissociative symptoms. The prevalence of BPD in community samples is estimated to be approximately 1% (Paris, 2005) and rises in psychiatric settings to 10% in outpatients and 25% in inpatients (Leichsenring et al., 2011). Several studies demonstrated that BPD is related to neuroanatomical changes (Schmahl and Bremner, 2006). However, there are differences between adults and adolescents with BPD.