دانلود مقاله ISI انگلیسی شماره 34479
عنوان فارسی مقاله

افزایش آستانه تشنج در طی الکتروشوک درمانی در بیماران مبتلا به اسکیزوفرنی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
34479 2000 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Seizure threshold rise during electroconvulsive therapy in schizophrenic patients
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 96, Issue 1, 25 September 2000, Pages 31–40

کلمات کلیدی
درمانی الکتروشوک - اسکیزوفرنی - افزایش آستانه تشنج - عوامل پیش بینی کننده برای افزایش آستانه - روش دوز - تیتراسیون - دوره ثبات سه هفته -
پیش نمایش مقاله
پیش نمایش مقاله افزایش آستانه تشنج در طی الکتروشوک درمانی در بیماران مبتلا به اسکیزوفرنی

چکیده انگلیسی

A rise in seizure threshold during a course of electroconvulsive therapy (ECT) has been demonstrated in patients with depression and mania, but no information has been available as to whether the same result occurs in schizophrenia. Ninety-three patients with schizophrenia underwent estimation of the seizure threshold by the dose-titration method, at the first and second, seventh, fourteenth, and twentieth treatments over an index ECT course. The 3-week stabilization period was used as a response criterion. Eighty-six patients (92%) showed a rise in threshold. The magnitude of increment was 269±244%. The rise in seizure threshold could be predicted by the number of treatments, initial seizure threshold and EEG seizure duration, and these factors explained 42% of the variance.

مقدمه انگلیسی

A substantial number of studies suggest that electroconvulsive therapy (ECT) possesses anticonvulsant properties. In animals, electroconvulsive shock has powerful anticonvulsant effects in blocking the development or aborting the expression of amygdala-kindled seizures (Post et al., 1986). In humans, an ECT-induced generalized seizure is immediately followed by a relative refractory period during which the threshold may be so elevated that restimulation often fails to elicit a seizure. It is also known that there is usually a progressive increase in seizure threshold over the treatment course (Sackeim et al., 1987a, Sackeim et al., 1987b, Coffey et al., 1995a and Coffey et al., 1995b). Moreover, ECT has previously been used to treat seizure disorders and their associated behavioral problems (Kalinowsky and Kennedy, 1943, Caplan, 1946, Taylor, 1946 and Sackeim et al., 1983). Prior ECT studies in depressed patients report 30–100% increases in seizure threshold over a treatment course, in which the threshold values were reported only at the sixth or eighth session (Malitz et al., 1986, Sackeim et al., 1987a, Sackeim et al., 1987b, Sackeim et al., 1991, Sackeim et al., 1993, Coffey et al., 1995b and Shapira et al., 1996). A similar finding has been reported in manic patients (Mukherjee, 1989). The present study was conducted in patients with schizophrenia, and seizure threshold was quantified over a longer ECT course to evaluate changes in threshold and their relationship to the therapeutic outcome and clinical variables.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.