دانلود مقاله ISI انگلیسی شماره 35075
عنوان فارسی مقاله

مورفولوژی قطب زمانی و آسیب شناسی روانی در مردان مبتلا به اسکیزوفرنی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
35075 2004 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Temporal pole morphology and psychopathology in males with schizophrenia
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 132, Issue 2, 15 December 2004, Pages 107–115

کلمات کلیدی
روان - مغز - ماده خاکستری - قطب زمانی - تصویربرداری عصبی - ام آر آی -
پیش نمایش مقاله
پیش نمایش مقاله مورفولوژی قطب زمانی و آسیب شناسی روانی در مردان مبتلا به اسکیزوفرنی

چکیده انگلیسی

A dysfunction of the paralimbic system has been implicated in the pathophysiology of schizophrenia. The temporal pole (TP) is a relevant component of the paralimbic circuit. Functional and structural imaging studies have shown circumscribed abnormalities in the TP. Subjects were 30 controls and 30 schizophrenia patients. Cortical surface size and gray matter volume of the TP were accurately measured to explore the morphology of the TP cortex and the relationship of TP measures to clinical variables in patients with schizophrenia. Correlations between structural measures and clinical dimensions, duration of illness, and cumulative neuroleptic exposure were determined. Neither macroscopic abnormalities in the TP nor differences in the pattern of asymmetry were demonstrated. The TP volume was correlated negatively to the psychotic and disorganized dimension scores. No other significant correlations were found. No morphological abnormalities in the TP were found in patients with schizophrenia. Interestingly, a reduction in the TP volume, a higher-order multimodal association cortex, was associated with the severity of disorganized and psychotic symptoms.

مقدمه انگلیسی

A general dysfunction of the limbic and paralimbic systems has been hypothesized to be an underlying pathophysiological mechanism in schizophrenia (Torrey and Peterson, 1974). Most investigations on morphological characteristics of the temporal lobe in schizophrenia have focused on the study of volumetric abnormalities of temporolimbic structures (i.e., hippocampus, parahippocampus gyrus, and amygdala), and less attention has been paid to possible abnormalities in one of the major paralimbic (mesocortical) components of the temporal lobe, the temporopolar cortex [or temporal pole (TP)]. From our laboratory and others, previous functional studies have shown that patients with schizophrenia have circumscribed abnormalities in several limbic/paralimbic areas, including the temporal pole in schizophrenia (Andreasen et al., 1996, Ragland et al., 1998 and Kim et al., 2000a). The TP is reciprocally connected with cortical and subcortical brain regions, as well as with other medial and lateral temporal regions (Markowitsch et al., 1985 and Moran et al., 1987), and is a component of the paralimbic circuit along with the orbitofrontal cortex (OFC) and the insular cortex (Mesulam and Mufson, 1982). The TP has been considered to be engaged in various cognitive functions, such as olfaction, social and emotional behavior, attentional and mnemonic processes, and auditory function, and therefore has been thought to play a role in affectional-sensory integration (Nakamura and Kubota, 1996, Gloor, 1997 and Mesulam, 2000). We have already described morphometric abnormalities of the other nodes of the paralimbic circuit (the OFC and the insular cortex) in patients with schizophrenia compared with healthy individuals (Crespo-Facorro et al., 2000a and Crespo-Facorro et al., 2000b). It is noteworthy that these structural anomalies in paralimbic regions have been associated with the severity of psychotic symptoms (i.e., hallucinations and delusions) and social dysfunction in schizophrenia (Crespo-Facorro et al., 2000a and Chemerinski et al., 2002). Previous voxel-based morphometric studies of temporal subregions in patients with chronic schizophrenia have pinpointed a significant volume reduction of bilateral temporal pole gray matter (Wright et al., 1999 and Gur et al., 2000). Nonetheless, further studies using anatomically defined (regions of interest) ROIs are needed to replicate these findings and to investigate the structure–function relationship of TP cortex. In the present study, we follow up our structural studies of paralimbic regions by exploring the morphology of the TP cortex using cortical parcellation in a group of patients with schizophrenia designed to represent a broad range of clinical variables such as duration of illness, neuroleptic exposure, and symptom severity. The relationship of TP measures to clinical variables, including symptom dimensions (negative, psychotic, and disorganized), cumulative dose of neuroleptic, and duration of illness is also investigated.

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