ویژگی های بزرگسالان ضعیف دارای ناتوانی ذهنی: چشم انداز مثبت زیست شناسی
|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|35285||2014||10 صفحه PDF||سفارش دهید||محاسبه نشده|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Research in Developmental Disabilities, Volume 35, Issue 1, January 2014, Pages 127–136
The current study focuses on the characteristics of older people with intellectual disabilities with the lowest frailty levels. Frailty is an increased risk of adverse health outcomes and dependency. Older adults with intellectual disabilities (ID) show more signs of early frailty than the general population. Knowledge of the least frail group characteristics may provide insight into possibilities to prevent early frailty in older people with intellectual disabilities. This study was part of the Healthy Aging and Intellectual Disability study (HA-ID) which incorporated 1050 adults aged 50 years and over with all levels of ID. Frailty was measured with a frailty index. The least frail group was selected based on a frailty index score ≤0.10. Odds ratios were used to compare the occurrence of health deficits in the least frail group to the remaining group. The least frail group consisted of 65 participants, corresponding with 6.6% of the study population. The least frail group was significantly younger, had less severe levels of ID, and less often Down syndrome than the remaining group. The lack of mobility and physical fitness limitations, dependence, no signs of depression/dementia, and little medical problems characterized the least frail group. The percentage of 50+ adults with intellectual disabilities within the least frail group is very low compared to that in the general aging population (>43%). Interventions to prevent or delay frailty in this population are highly recommended and can focus on health characteristics of the least frail group.
Most of today's medical research is concentrated on the question: “What causes pathology?” focusing on the understanding of disease causes and the invention of new therapies is considered the so-called ‘negative biology’. Controversially, ‘positive biology’ aims at understanding why some people age without the diseases and problems that many others suffer from. This perspective receives far less attention, although it could offer more insight in successful aging and generate a greater health benefit for the older adults than would eliminating one specific disease (Farrelly, 2012). A useful method for understanding the process of aging and healthy aging is frailty. Frailty is a state of increased risk of adverse health outcomes, which reflects multisystem physiological changes and is highly associated with age (Abellan van Kan et al., 2008). A recent study showed that very high levels of frailty (deficit accumulation) were found in older people with intellectual disabilities (ID; Schoufour, Mitnitski, Rockwood, Evenhuis, & Echteld, 2013). The current paper adopts a positive biology perspective by analysing the characteristics of older people with ID with the lowest frailty levels. There are several methods for measuring frailty. One widely used approach is the frailty index (Mitnitski, Mogilner, & Rockwood, 2001). The frailty index is based on a non-specific accumulation of deficits in several health domains. Deficits are defined as diseases, symptoms, disabilities, laboratory results or health related questionnaires and must cover a range of systems. A frailty index score (FI-score) is calculated by dividing the sum of deficits present by the total number of deficits measured, resulting in a score between 0 and 1 (Searle, Mitnitski, Gahbauer, Gill, & Rockwood, 2008). The FI-score is highly associated with the risk of deterioration of health, dependence, and hospital admission, and frail people have decreased life expectancies (Rockwood & Mitnitski, 2007). Recently, we developed a frailty index for older adults with ID (Schoufour et al., 2013) based on data collected in the Healthy Aging and Intellectual Disability study (HA-ID), a cross-sectional study performed in 1050 participants aged 50 years and over in The Netherlands (Hilgenkamp et al., 2011a and Hilgenkamp et al., 2011b). In addition to general aging problems adults with ID have an increased risk of motor and sensory disabilities, chronic diseases (e.g. epilepsy), and mental health problems (Evenhuis et al., 2001, Meuwese-Jongejeugd et al., 2006 and Splunder van et al., 2006). These factors could lead to increased frailty across the lifespan, and in this way to early frailty in older adults with ID. Although the frailty index developed for older adults with ID has not yet shown to be related to negative health outcomes, preliminary data show that average frailty levels are high, and that frailty levels in older adults with ID aged 50 are comparable to frailty levels of older people without ID aged 70 and above. Furthermore it was shown that more severe ID and higher age were associated with an increased frailty score. Frailty in this population is of growing interest, since life expectancy of adults with ID is approaching the general public's life expectancy (Bittles et al., 2002 and Patja et al., 2000). The increased life expectancy and the high number of frail people make interventions to prevent or delay frailty urgently required. In the perspective of positive biology, it would be interesting to know why some adults maintain very low frailty levels at high ages and remain in the so called zero-state – having no measured deficits – for a long time. Previous studies show that roughly 3% (70 years and above; Searle et al., 2008) and 9% (50 years and above; Romero-Ortuno & Kenny, 2012) of the general population can be classified in the zero state. Across the lifespan, these “fit” adults are far less likely to die within 12 years and stay relatively fit over time (Rockwood, Song, & Mitnitski, 2011). Positive biology would promote the use of health information of these fit older people for the prevention of future frailty (Farrelly, 2012). Among participants of the HA-ID study no one was classified in the zero state (Schoufour et al., 2013). However, there are older adults with ID who are relatively fit compared to others in the population. Therefore, in this study we investigated characteristics of the adults scoring lowest on the frailty index. More specifically: Which deficits are found significantly less often in older adults with ID with low FI-scores than in the remaining group?