مطالعه مقدماتی تصویربرداری تشدید مغناطیسی مورفومتریک حجم منطقه ای مغز در اختلال بدریخت انگاری
|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|35536||2003||7 صفحه PDF||سفارش دهید||محاسبه نشده|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Psychiatry Research: Neuroimaging, Volume 122, Issue 1, 20 January 2003, Pages 13–19
Morphometric magnetic resonance imaging (MRI) was used to compare regional brain volumes in eight women with body dysmorphic disorder (BDD) and eight healthy comparison subjects. The BDD group exhibited a relative leftward shift in caudate asymmetry and greater total white matter vs. the comparison group. Findings with respect to the caudate nucleus are consistent with both the conceptualization of BDD as an obsessive–compulsive spectrum disorder, and the ‘striatal topography model’ of obsessive–compulsive disorders.
The neurobiological basis of body dysmorphic disorder (BDD) remains poorly understood. Though BDD has continued to be classified as a somatoform disorder (American Psychiatric Association 1994), alternative schemes have suggested that BDD might be better conceptualized as one of a group of so-called ‘Obsessive–Compulsive Spectrum Disorders’ (OCSDs) along with obsessive–compulsive disorder (OCD), Tourette syndrome (TS) and trichotillomania (TTM) (e.g. Hollander et al., 1993). Some researchers have also proposed that BDD might be conceptualized as one of a group of so-called ‘Affective Spectrum Disorders’, along with major depressive disorder (Phillips et al., 1995b). In the current study, we employed morphometric magnetic resonance imaging (MRI) methods to test specific hypotheses regarding differences in regional brain volumes between subjects with BDD and a psychiatrically healthy comparison group. Our a priori hypotheses were selected to investigate the theory that BDD is an OCSD or an affective spectrum disorder; the specific hypotheses were guided by the existing literature pertaining to OCSDs and affective disorders. Morphometric MRI studies of OCSDs have most consistently found volumetric abnormalities of the striatum (see Rauch and Baxter, 1998). The ‘striatal topography model’ of OCSDs (see Baxter et al., 1990 and Rauch et al., 1998) suggests that these disorders share striatal pathology as a common attribute, and that the distribution of pathology among striatal territories governs the presenting clinical phenomena; specifically, OCSDs primarily characterized by cognitive or visuospatial symptoms, such as OCD or BDD, are associated with caudate abnormalities, whereas OCSDs primarily characterized by sensorimotor symptoms, such as TS and TTM, are associated with putamen abnormalities. In fact, by MRI, striatal findings in OCD have principally implicated the caudate nucleus (e.g. see Robinson et al., 1995), whereas studies of TS (e.g. Peterson et al., 1993 and Singer et al., 1993) and TTM (O'Sullivan et al., 1997) have shown analogous abnormalities involving the putamen or lenticulate. Furthermore, though in some instances the observed abnormalities entail reduced striatal volumes, in several instances the reported findings suggest abnormalities in striatal asymmetry across hemispheres (i.e. laterality quotient) (see Jenike et al., 1996, Singer et al., 1993 and Peterson et al., 1993). In addition, two MRI studies of OCD have found diffuse reductions in white matter volume (Breiter et al., 1994 and Jenike et al., 1996). Thus, taken together, prior imaging research prompted the hypotheses that if BDD is to be conceptualized as an OCSD, subjects should exhibit abnormal striatal and white matter volumes; more specifically, volumetric abnormality of the caudate nucleus manifested as either reduced volume or a shift in asymmetry, as well as reduced white matter volume. In contrast, though MRI studies of affective disorders have also occasionally found basal ganglia abnormalities (see Dougherty and Rauch, 1997), recent structural findings in primary major depression have principally implicated the hippocampus (e.g. see Bremner et al., 2000, Sheline, 2000, Sheline et al., 1996 and Sheline et al., 1999) rather than the striatum (e.g. see Pillay et al., 1998 and Lenze and Sheline, 1999). Furthermore, reduced hippocampal volumes in major depression are consistent with emerging theories of pathophysiology as well as potential mechanisms of antidepressant action (see Duman et al., 1997 and Sapolsky, 2001). Thus, taken together, prior imaging research prompted the hypothesis that if BDD is to be conceptualized as an affective spectrum disorder, subjects would exhibit reduced hippocampal volumes.