دانلود مقاله ISI انگلیسی شماره 35899
عنوان فارسی مقاله

اکسی توسین در منطقه پری اپتیک داخلی رفتار جنسی نر در موش صحرایی را تسهیل می کند

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
35899 2011 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Hormones and Behavior, Volume 59, Issue 4, April 2011, Pages 435–443

کلمات کلیدی
Oxytocin (OT) belongs to a highly conserved family of peptides that regulate social and reproductive behaviors in vertebrates (Boyd - 1997 and Mahlmann et al - - 1994) - OT promotes female rat sexual and maternal behaviors (Caldwell et al - - 1989 - Caldwell et al - - 1994 - Pedersen et al - - 1982 and Pedersen et al - - 1994) and regulates male reproductive function - OT neurons in the male rat paraventricular nucleus of the hypothalamus (PVN) are activated (i - e - - Fos-immunoreactive - -ir) following copulation (Witt and Insel - 1994) or ex copula non-contact erections ( Baskerville et al - - 2009) - Infusion of nanogram (ng) amounts of OT into the lateral ventricles stimulates copulation in male rats ( Argiolas and Gessa - 1991 and Arletti et al - - 1985) - these effects are blocked by pretreatment with an OT receptor (OTR) antagonist (OTA) ( Arletti et al - - 1992) - Intracerebroventricular (icv) administration of an OTA increases intromission and ejaculation latencies and decreases mounts and intromissions ( Argiolas et al - - 1988) - In addition - OT binding sites and varicosities have been identified in thoracolumbar and lumbosacral spinal segments that control penile erection in rats - and OTR is expressed in penile tissue in men ( Veronneau-Longueville et al - - 1999 and Vignozzi et al - - 2004) - OT treatment (icv) induces ex copula penile erection in male rats ( Argiolas et al - - 1985) - these effects are dependent - in part - on stimulation of OTRs in the PVN and CA1 region of the hippocampus ( Melis et al - - 1986) - Male rats that fail to copulate to ejaculation have lower levels of OT mRNA in the PVN - compared to sexually vigorous males ( Arletti et al - - 1997) - OT can also restore copulation in males whose copulatory behavior had been impaired by chronic fluoxetine ( Cantor et al - - 1999) - Plasma concentrations of OT increase during the sexual response in rats and humans ( Carmichael et al - - 1987 and Stoneham et al - - 1985) - and a link between sexual impotence and reduced central OT production has been established in the male rat ( Arletti et al - - 1997) - OT and the mesolimbic dopamine system interact to promote male rat sexual behavior - Microinjection of OT into the PVN - ventral tegmental area (VTA) - ventral subiculum - or posteromedial cortical nucleus of the amygdala induces penile erection and increases dopamine levels in the nucleus accumbens (NAcc) (Melis et al - - 2007 - Melis et al - - 2009 - Succu et al - - 2007 and Succu et al - - 2008) - OTA treatment (icv) reduces non-contact erections in the presence of a receptive female (Melis et al - - 1999) - and intraperitoneal (ip) injections of OT stimulate the onset of copulation in aging (20-month old) male rats (Arletti et al - - 1990 and Arletti et al - - 1992) - Taken together - the available data suggest that OT is involved in both the consummatory and appetitive phases of the sexual response in males - Most pharmacological studies of the effects of OT on male sexual behavior have used icv administration of OT or OTA - the relatively few researchers who tested site-specific effects focused primarily on the PVN - VTA - hippocampus - and amygdala - Less attention has been given to the medial preoptic area (MPOA) - a major site of integration for male sexual behavior (reviewed in Hull et al - - 2002 and Hull and Rodriguez-Manzo - 2009) - OT-producing neurons and OT binding sites have been identified in the MPOA of male rats (Tribollet et al - - 1992) - and OT-containing MPOA neurons are activated (Fos-ir) by copulation (Baskerville et al - - 2009) - In female rats - a few OT-ir neurons in the MPOA project indirectly to the clitoris and vagina - suggesting a role for OT in the MPOA in the control of sexual function in females (Gelez et al - - 2010) - Thus - a major goal of the present study is to determine whether OT acts in the MPOA to facilitate male sexual behavior - There is a great deal of variability in reproductive behavior of rodents - In female rats - levels of OTR binding are higher in high licking and grooming (LG) mothers than in low LG mothers (Francis et al - - 2000) - In addition - more maternally responsive females have higher levels of OTR binding in the amygdala - bed nucleus of the stria terminalis - and MPOA compared to mothers that are less responsive (Champagne et al - - 2001) - We wished to test whether differences in OT or OTR activity in the MPOA may be associated with differences in male sexual behavior - Using factor analysis - Sachs (1978) condensed 10 measures of copulatory behavior into 4 factors - An initiation factor comprises latencies to the first mount and intromission - Intromission count factor corresponds to the number of intromissions required to elicit an ejaculation - Hit rate factor is the ratio of successful penile intromissions to total mount attempts - Copulatory rate factor includes the latency to the first ejaculation - latency to the resumption of copulation following an ejaculation - and average time interval between intromissions - Efficiency generally refers to the ability to accomplish a goal effectively - with minimal waste of time or resources - Therefore - we hypothesized that intra-MPOA injection of OT would improve sexual efficiency by facilitating one or more of the above factors—i - e - - increase hit rate factor and decrease initiation - copulatory rate - and intromission count factors - whereas injection of an OTA was expected to inhibit one or more of these factors - We also hypothesized that sexual efficiency would be correlated with OTR binding in the MPOA of sexually experienced male rats -
پیش نمایش مقاله
پیش نمایش مقاله اکسی توسین در منطقه پری اپتیک داخلی رفتار جنسی نر در موش صحرایی را تسهیل می کند

چکیده انگلیسی

Oxytocin; Oxytocin receptor; Oxytocin receptor antagonist; Male sexual behavior; Sexual behavior; Reproductive behavior; Medial preoptic area

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.