دانلود مقاله ISI انگلیسی شماره 35947
عنوان فارسی مقاله

نشانگرهای بیولوژیکی و روانی استرس در انسان: تمرکز بر تست استرس اجتماعی ترایر

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
35947 2014 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuroscience & Biobehavioral Reviews, Volume 38, January 2014, Pages 94–124

کلمات کلیدی
استرس - کورتیزول - ACTH - سروتونین - محور HPA - سمپاتیک آدرنال-مدولاری سیستم - محور مغز روده - ضربان قلب - سیستم ایمنی بدن - ژنتیک
پیش نمایش مقاله
پیش نمایش مقاله نشانگرهای بیولوژیکی و روانی استرس در انسان: تمرکز بر تست استرس اجتماعی ترایر

چکیده انگلیسی

Validated biological and psychological markers of acute stress in humans are an important tool in translational research. The Trier Social Stress Test (TSST), involving public interview and mental arithmetic performance, is among the most popular methods of inducing acute stress in experimental settings, and reliably increases hypothalamic-pituitary-adrenal axis activation. However, although much research has focused on HPA axis activity, the TSST also affects the sympathetic-adrenal-medullary system, the immune system, cardiovascular outputs, gastric function and cognition. We critically assess the utility of different biological and psychological markers, with guidance for future research, and discuss factors which can moderate TSST effects. We outline the effects of the TSST in stress-related disorders, and if these responses can be abrogated by pharmacological and psychological treatments. Modified TSST protocols are discussed, and the TSST is compared to alternative methods of inducing acute stress. Our analysis suggests that multiple readouts are necessary to derive maximum information; this strategy will enhance our understanding of the psychobiology of stress and provide the means to assess novel therapeutic agents.

مقدمه انگلیسی

Exposure to a situation perceived as threatening or excessively demanding (a stressor) leads to the release of chemicals which can help cope with the stressor (e.g. Joels and Baram, 2009 and Schwabe et al., 2012). Acute stress can alter numerous biological functions, such as the hypothalamic-pituitary-adrenal (HPA) axis (Foley and Kirschbaum, 2010), the immune system (Steptoe et al., 2007), the autonomic nervous system (Xhyheri et al., 2012), and the enteric nervous system (Ziegler, 2012). Psychologically, acute stress is a subjectively negative experience (but see Jamieson et al., 2013), and can have positive as well as negative effects on cognition (Lupien et al., 2007 and Starcke and Brand, 2012). Although acute stress is important for responding to threatening situations, chronic stress is damaging to health (McEwen, 2007). Over time, stressful life events can induce chronic stimulation of the HPA axis, leading to depression (Checkley, 1992 and Juruena et al., 2011), and poorer prognosis for cancer and heart disease (Maddock and Pariante, 2001). Early-life stress is associated with disorders such as depression (Batten et al., 2004 and Dinan, 2005), post-traumatic stress disorder (Koenen et al., 2007), and irritable bowel syndrome (Mayer et al., 2001), and chronic work stress can exacerbate anxiety and depression (Smith, 2000). Moreover, chronic stress will result in changes in subsequent reactivity to an acute stressor (e.g. Chatkoff et al., 2010, Low et al., 2009 and Roth et al., 2012). Given the contrast between acute and chronic stress, it is of interest to examine the effects of acute stress in the context of disorders associated with chronic stress. Preclinical methods for inducing stress are well established (Buynitsky and Mostofsky, 2009) and preclinical research has provided insight into the effects of stress, the possible role of factors such as neurotransmitters (e.g. Browne et al., 2011, Cryan et al., 2004 and Julio-Pieper et al., 2012) and the interaction between the central and enteric nervous systems (Cryan and Dinan, 2012). There is now growing recognition that preclinical efforts to gain greater insight into the effects of stress and stress mechanisms need to be bolstered by translationally relevant studies in human populations. Accordingly, a stressor which can reliably produce a psychophysiological stress response in humans under controlled conditions is of immense value to this field.

خرید مقاله
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