دانلود مقاله ISI انگلیسی شماره 37037
عنوان فارسی مقاله

اختلال آموزش معکوس تبعیض اولیه و یادگیری فضایی حفظ شده در یک مطالعه طولی از موش Tg2576 APPsw

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
37037 2007 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 28, Issue 8, August 2007, Pages 1248–1257

کلمات کلیدی
قشر فرونتال - هیپوکامپ - حافظه کاری - T-پیچ و خم - پیچ و خم آب - تنظیم تغییر - آمیلوئید β - بیماری آلزایمر
پیش نمایش مقاله
پیش نمایش مقاله اختلال آموزش معکوس تبعیض اولیه و یادگیری فضایی حفظ شده در یک مطالعه طولی از موش Tg2576 APPsw

چکیده انگلیسی

To understand the relationship between amyloid-β and cognitive decline in Alzheimer's disease, we evaluated cortical and hippocampal function in a transgenic mouse model of amyloid over-expression in Alzheimer's disease, the Tg2576 mouse. Tg2576 mice and their non-transgenic littermates were assessed at both 6 and 14 months of age in a battery of cognitive tests: attentional set-shifting, water maze spatial reference memory and T-maze working memory. Spatial reference memory was not affected by Tg status at either age. Working memory was only affected by age, with 6-month-old mice performing better than 14-month-old ones. Older mice were also significantly impaired on reversal learning and on the intra- and extra-dimensional shift in attentional set-shifting. A significant transgene effect was apparent in reversal learning, with Tg2576 mice requiring more trials to reach criterion at 6 months old. These data indicate that the effects of normal aging in C57B6 × SJL F1 mice are most pronounced on putative frontal cortex-dependent tasks and that increasing Aβ load only affects discrimination reversal learning in our study.

مقدمه انگلیسی

Tg2576 mice, which over-express the human APP Swedish mutation (K670N, M671L), are widely studied as an Alzheimer's disease (AD) transgenic mouse model [23]. This transgenic model develops a pathological hallmark of AD with increasing age, Aβ plaque deposition. Amyloid plaques are distributed in cortical and hippocampal regions after 10 months of age in a pattern similar to that observed in humans [24] and [50]. Levels of Aβ 1–40 and 1–42 also increase prior to plaque deposition, with measurable levels apparent by 6–8 months of age [24] and [53]. Age-dependent memory loss has been observed in Tg2576 mice [26] and [53], and some studies argue that the cognitive impairment is associated with soluble brain Aβ [27], [32] and [53].

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.