دانلود مقاله ISI انگلیسی شماره 37039
عنوان فارسی مقاله

اداره درون هیپوکامپی از یک آنتاگونیست گیرنده NMDA باعث اختلال در آموزش معکوس تبعیض فضایی در نوازد موش می شود

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
37039 2009 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Intrahippocampal administration of an NMDA-receptor antagonist impairs spatial discrimination reversal learning in weanling rats
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 92, Issue 1, July 2009, Pages 89–98

کلمات کلیدی
توسعه - آموزش معکوس - هیپوکامپ - موش صحرایی - یادگیری فضایی
پیش نمایش مقاله
پیش نمایش مقاله اداره درون هیپوکامپی از یک آنتاگونیست گیرنده NMDA باعث اختلال در آموزش معکوس تبعیض فضایی در نوازد موش می شود

چکیده انگلیسی

Systemic administration of MK-801, an NMDA-receptor antagonist, impairs reversal learning in weanling rats [Chadman, K.K., Watson, D.J., & Stanton, M.E. (2006). NMDA-receptor antagonism impairs reversal learning in developing rats. Behavioral Neuroscience, 120(5), 1071–1083]. The brain systems responsible for this effect are not known in either adult or young animals. This study tested the hypothesis that hippocampal NMDA receptors are engaged in weanling-age rats during spatial discrimination reversal training in a T-maze. In Experiment 1, 26-day-old Long-Evans rats (P26) showed a dose-related impairment on this task following bilateral intrahippocampal administration of either 2.5 or 5.0 μg MK-801 or saline vehicle during the reversal training phase only. In Experiment 2, P26 rats were trained on the same task, but received intrahippocampal MK-801 (2.5 μg) during acquisition, reversal, both, or neither. MK-801 failed to impair acquisition, ruling out nonspecific “performance effects” of the drug. MK-801 impaired reversal irrespective of drug treatment during acquisition. NMDA-receptor antagonism in the hippocampus is sufficient to account for the previously reported effects of systemic MK-801 on reversal of T-maze position discrimination.

مقدمه انگلیسی

The N-methyl-d-Aspartate (NMDA) receptor subtype of glutamate receptors plays a substantial role in neural physiology, synaptic plasticity, and behavioral learning and memory. These roles include, but are not limited to, the molecular/cellular basis of short- and long-term memory formation, the induction and maintenance of long-term potentiation (LTP), as well spatial learning and memory that depends upon the hippocampus (Morris et al., 1986, O’Keefe and Nadel, 1978 and Shapiro, 2001). NMDA receptors are heavily concentrated in the hippocampal formation, cortex, and striatum (Wong et al., 1986 and Wong et al., 1988). These same brain regions are essential for spatial learning and memory, contextual memory, and higher-order cognitive learning tasks in adult animals. It is currently unknown if these same brain regions are involved in reversal learning during early ontogeny.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.