دانلود مقاله ISI انگلیسی شماره 39659
ترجمه فارسی عنوان مقاله

گیرنده های مینرالوکورتیکوئیدها در کنترل انگیختگی عاطفی و حافظه ترس

عنوان انگلیسی
Mineralocorticoid receptors in control of emotional arousal and fear memory
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
39659 2009 7 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Hormones and Behavior, Volume 56, Issue 2, August 2009, Pages 232–238

ترجمه کلمات کلیدی
گیرنده مینرالوکورتیکوئیدها - مغز - هیجانی - فشار - رفتار غیرشرطی - ترس شرطی
کلمات کلیدی انگلیسی
Mineralocorticoid receptor; Forebrain; Emotion; Stress; Unconditioned behavior; Fear conditioning
پیش نمایش مقاله
پیش نمایش مقاله  گیرنده های مینرالوکورتیکوئیدها در کنترل انگیختگی عاطفی و حافظه ترس

چکیده انگلیسی

The stress hormone corticosterone acts via two receptor types in the brain: the mineralocorticoid (MR) and the glucocorticoid receptor (GR). Both receptors are involved in processing of stressful events. A disbalance of MR:GR functions is thought to promote stress-related disorders. Here we studied the effect of stress on emotional and cognitive behaviors in mice with forebrain-specific inactivation of the MR gene (MRCaMKCre, 4 months old; and control littermates). MRCaMKCre mice responded to prior stress (5 min of restraint) with higher arousal and less locomotor activity in an exploration task. A fear conditioning paradigm allowed assessing in one experimental procedure both context- and cue-related fear. During conditioning, MRCaMKCre mice expressed more cue-related freezing. During memory test, contextual freezing remained potentiated, while control mice distinguished between cue (more freezing) and context episodes (less freezing) in the second memory test. At this time, plasma corticosterone levels of MRCaMKCre mice were 40% higher than in controls. We conclude that control of emotional arousal and adaptive behaviors is lost in the absence of forebrain MR, and thus, anxiety-related responses are and remain augmented. We propose that such a disbalance in MR:GR functions in MRCaMKCre mice provides the conditions for an animal model for anxiety-related disorders.