دانلود مقاله ISI انگلیسی شماره 39775
عنوان فارسی مقاله

عملکرد غیر طبیعی گابا و چهره پردازی در اسکیزوفرنی: مطالعه دارویی fMRI

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
39775 2015 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Abnormal GABAergic function and face processing in schizophrenia: A pharmacologic-fMRI study
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Schizophrenia Research, Volume 168, Issues 1–2, October 2015, Pages 338–344

کلمات کلیدی
fMRI - روان پریشی - شناخت اجتماعی - هیجانی - بنزودیازپین
پیش نمایش مقاله
پیش نمایش مقاله عملکرد غیر طبیعی گابا و چهره پردازی در اسکیزوفرنی: مطالعه دارویی fMRI

چکیده انگلیسی

The involvement of the gamma-aminobutyric acid (GABA) system in schizophrenia is suggested by postmortem studies and the common use of GABA receptor-potentiating agents in treatment. In a recent study, we used a benzodiazepine challenge to demonstrate abnormal GABAergic function during processing of negative visual stimuli in schizophrenia. This study extended this investigation by mapping GABAergic mechanisms associated with face processing and social appraisal in schizophrenia using a benzodiazepine challenge. Fourteen stable, medicated schizophrenia/schizoaffective patients (SZ) and 13 healthy controls (HC) underwent functional MRI using the blood oxygenation level-dependent (BOLD) technique while they performed the Socio-emotional Preference Task (SePT) on emotional face stimuli (“Do you like this face?”). Participants received single-blinded intravenous saline and lorazepam (LRZ) in two separate sessions separated by 1–3 weeks. Both SZ and HC recruited medial prefrontal cortex/anterior cingulate during the SePT, relative to gender identification. A significant drug by group interaction was observed in the medial occipital cortex, such that SZ showed increased BOLD signal to LRZ challenge, while HC showed an expected decrease of signal; the interaction did not vary by task. The altered BOLD response to LRZ challenge in SZ was significantly correlated with increased negative affect across multiple measures. The altered response to LRZ challenge suggests that abnormal face processing and negative affect in SZ are associated with altered GABAergic function in the visual cortex, underscoring the role of impaired visual processing in socio-emotional deficits in schizophrenia.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.