دانلود مقاله ISI انگلیسی شماره 39783
عنوان فارسی مقاله

ارتباط عصبی و عاطفی چهره پردازی در افسردگی نوجوانان: یک رویکرد بعدی با تمرکز بر فقدان لذت و شدت بیماری

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
39783 2014 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
The neural correlates of emotional face-processing in adolescent depression: a dimensional approach focusing on anhedonia and illness severity
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 224, Issue 3, 30 December 2014, Pages 234–241

کلمات کلیدی
نوجوانان - افسردگی - فقدان لذت - درک احساسات - fMRI - چهره ها
پیش نمایش مقاله
پیش نمایش مقاله ارتباط عصبی و عاطفی چهره پردازی در افسردگی نوجوانان: یک رویکرد بعدی با تمرکز بر فقدان لذت و شدت بیماری

چکیده انگلیسی

Deficits in emotion processing, a known clinical feature of major depressive disorder (MDD), have been widely investigated using emotional face paradigms and neuroimaging. However, most studies have not accounted for the high inter-subject variability of symptom severity. Similarly, only sparse research has focused on MDD in adolescence, early in the course of the illness. Here we sought to investigate neural responses to emotional faces using both categorical and dimensional analyses with a focus on anhedonia, a core symptom of MDD associated with poor outcomes. Nineteen medication-free depressed adolescents and 18 healthy controls (HC) were scanned during presentation of happy, sad, fearful, and neutral faces. ANCOVAs and regressions assessed group differences and relationships with illness and anhedonia severity, respectively. Findings included a group by valence interaction with depressed adolescents exhibiting decreased activity in the superior temporal gyrus (STG), putamen and premotor cortex. Post-hoc analyses confirmed decreased STG activity in MDD adolescents. Dimensional analyses revealed associations between illness severity and altered responses to negative faces in prefrontal, cingulate, striatal, and limbic regions. However, anhedonia severity was uniquely correlated with responses to happy faces in the prefrontal, cingulate, and insular regions. Our work highlights the need for studying specific symptoms dimensionally in psychiatric research.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.