دانلود مقاله ISI انگلیسی شماره 40046
عنوان فارسی مقاله

سیستم اندوکانابینوئید و پردازش عاطفی: مطالعه دارویی fMRI با Δ9 تتراهیدروکانابینول

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
40046 2013 11 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
The endocannabinoid system and emotional processing: A pharmacological fMRI study with ∆9-tetrahydrocannabinol
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 23, Issue 12, December 2013, Pages 1687–1697

کلمات کلیدی
سیستم اندوکانابینوئید - پردازش عاطفی - MRI عملکردی - Δ9 تتراهیدروکانابینول (THC)
پیش نمایش مقاله
پیش نمایش مقاله سیستم اندوکانابینوئید و پردازش عاطفی: مطالعه دارویی fMRI با Δ9 تتراهیدروکانابینول

چکیده انگلیسی

Various psychiatric disorders such as major depression are associated with abnormalities in emotional processing. Evidence indicating involvement of the endocannabinoid system in emotional processing, and thus potentially in related abnormalities, is increasing. In the present study, we examined the role of the endocannabinoid system in processing of stimuli with a positive and negative emotional content in healthy volunteers. A pharmacological functional magnetic resonance imaging (fMRI) study was conducted with a placebo-controlled, cross-over design, investigating effects of the endocannabinoid agonist ∆9-tetrahydrocannabinol (THC) on brain function related to emotional processing in 11 healthy subjects. Performance and brain activity during matching of stimuli with a negative (‘fearful faces’) or a positive content (‘happy faces’) were assessed after placebo and THC administration. After THC administration, performance accuracy was decreased for stimuli with a negative but not for stimuli with a positive emotional content. Our task activated a network of brain regions including amygdala, orbital frontal gyrus, hippocampus, parietal gyrus, prefrontal cortex, and regions in the occipital cortex. THC interacted with emotional content, as activity in this network was reduced for negative content, while activity for positive content was increased. These results indicate that THC administration reduces the negative bias in emotional processing. This adds human evidence to support the hypothesis that the endocannabinoid system is involved in modulation of emotional processing. Our findings also suggest a possible role for the endocannabinoid system in abnormal emotional processing, and may thus be relevant for psychiatric disorders such as major depression.

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