دانلود مقاله ISI انگلیسی شماره 40060
عنوان فارسی مقاله

عدم تفکیک پردازش عاطفی از پردازش شناختی و حسی-حرکتی در افسردگی اساسی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
40060 2011 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Failure to segregate emotional processing from cognitive and sensorimotor processing in major depression
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 193, Issue 3, 30 September 2011, Pages 144–150

کلمات کلیدی
fMRI - جسم مخطط شکمی - اتصال عملکردی - تجزیه و تحلیل مولفه های اصلی - پیش فرض حالت شبکه - تصویربرداری عصبی
پیش نمایش مقاله
پیش نمایش مقاله عدم تفکیک پردازش عاطفی از پردازش شناختی و حسی-حرکتی در افسردگی اساسی

چکیده انگلیسی

Most functional neuroimaging studies of major depressive disorder (MDD) employ univariate methods of statistical analysis to localize abnormalities of neural activity. Less has been done to investigate functional relations between these regions, or with regions not usually implicated in depression. Examination of intraneuronal and interneural network relations is important for the advancement of emerging network models for MDD. Principal component analysis (PCA), a multivariate statistical method, was used to examine differences in functional connectivity between 10 unmedicated patients with MDD and 12 healthy subjects engaged in a positive word viewing task. In healthy subjects, principal component (PC) 1 (33% variance) revealed functional connectivity of task-specific sensory, linguistic, and motor regions, along with functional anticorrelations in the default mode network; PC2 (10% variance) displayed functional connectivity of areas involved in emotional processing. This segregation of functions did not occur in the depressed group, where regions involved in emotional functions appeared in PC1 (34% variance) co-varying with those involved in linguistic, motor, and default mode network processing. The lack of segregation of emotional processing from cognitive and sensorimotor functions may represent a systems level neural substrate for a core phenomenon of depression: the interconnection of affective disturbance with experience, cognition, and behavior.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.