دانلود مقاله ISI انگلیسی شماره 40203
عنوان فارسی مقاله

نرم نشانه های عصبی از ویژگی های یک تفکیک دوگانه در درون نظام زبان در سندرم ویلیامز

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
40203 2010 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Neurological soft signs feature a double dissociation within the language system in Williams syndrome
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 48, Issue 11, September 2010, Pages 3298–3304

کلمات کلیدی
سندرم ویلیامز - الاستین - فلورسنت در هیبریدیزاسیون درجا -
پیش نمایش مقاله
پیش نمایش مقاله نرم نشانه های عصبی از ویژگی های یک تفکیک دوگانه در درون نظام زبان در سندرم ویلیامز

چکیده انگلیسی

The neurocognitive profile of Williams-Beuren syndrome (WBS) is characterized by visuospatial deficits, apparently fluent language, motor soft signs, and hypersociability. We investigated the association between neuromotor soft signs and visuospatial, executive-attentive, mnestic and linguistic functions in a group of 26 children and young adults with WBS. We hypothesized that neurological soft signs could be an index of subtle neurofunctional deficits and thus provide a behavioural window into the processes underlying neurocognition in Williams-Beuren syndrome. Dysmetria and dystonic movements were selected as grouping neurological variables, indexing cerebellar and basal ganglia dysfunction, respectively. No detrimental effects on visuospatial/visuoconstructive skills were evident following the presence of either neurological variable. As for language skills, participants with dysmetria showed markedly reduced expressive syntactic and lexico-semantic skills as compared to non-affected individuals, while no difference in chronological age was evident. Participants with dystonic movements showed reduced receptive syntax and increased lexical comprehension skills as compared to non-affected individuals, the age factor being significant. In both instances, the effect size was greater for syntactic measures. We take these novel findings as suggestive of a double dissociation between expressive and receptive skills at sentence level within the WBS linguistic phenotype. The investigation of neuromotor soft signs and neuropsychological functions may provide a key to new non-cortico-centric genotype/phenotype relationships.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.