دانلود مقاله ISI انگلیسی شماره 40357
عنوان فارسی مقاله

لیمبیک در مقابل هدف شناختی برای تحریک عمقی مغز در افسردگی مقاوم به درمان: اکومبنس امیدبخش تر از نزدیکی دم

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
40357 2014 11 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Limbic versus cognitive target for deep brain stimulation in treatment-resistant depression: Accumbens more promising than caudate ☆
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 24, Issue 8, August 2014, Pages 1229–1239

کلمات کلیدی
تحریک عمقی مغز - اکومبنس - دمی - افسردگی مقاوم به درمان - محاکمه درمانی
پیش نمایش مقاله
پیش نمایش مقاله لیمبیک در مقابل هدف شناختی برای تحریک عمقی مغز در افسردگی مقاوم به درمان: اکومبنس امیدبخش تر از نزدیکی دم

چکیده انگلیسی

High-frequency deep brain stimulation (DBS) represents a major stake for treatment for treatment-resistant depression (TRD). We describe a preliminary trial of DBS of two potential brain targets in chronic TRD: the nucleus accumbens (Acb) and, in the event of failure, the caudate nucleus. Patients were followed for 6 months before surgery (M0). From M1 to M5, they underwent stimulation of the Acb target. PET scans allowed us to track metabolic modifications resulting from this stimulation. The caudate target of nonresponders was stimulated between M5 and M9. Patients then entered an extension phase, in which it was possible to adapt stimulation parameters and treatments. Six patients were included and four were operated on. At M5, none of the patients were either responders or remitters, but we did observe a decrease in Hamilton Depression Rating Scale (HDRS) scores. Three patients were switched to caudate stimulation, but no improvement was observed. During the extension phase, the Acb target was stimulated for all patients, three of whom exhibited a significant response. A decrease in glucose metabolism was observed after Acb stimulation, in the posterior cingulate gyrus, left frontal lobe, superior and medial gyrus, and bilateral cerebellum. An increase in metabolism was observed in the bilateral frontal lobe (superior gyrus), left frontal lobe (medial gyrus), and right limbic lobe (anterior cingulate gyrus). The results of this trial suggest that Acb is a more promising target than the caudate. NCT01569711.

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