دانلود مقاله ISI انگلیسی شماره 40371
عنوان فارسی مقاله

مورد تجزیه و تحلیل خطا در رنگ ماتریس پیشرو ریون در سندرم ویلیامز

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
40371 2012 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 201, Issue 1, 30 January 2012, Pages 78–87

کلمات کلیدی
اختلال وسواسی-اجباری - SPECT - مدل حیوانی - تصویربرداری عصبی - سروتونین - دوپامین
پیش نمایش مقاله
پیش نمایش مقاله مورد تجزیه و تحلیل خطا در رنگ ماتریس پیشرو ریون در سندرم ویلیامز

چکیده انگلیسی

Neuro-imaging studies have shown altered, yet often inconsistent, serotonergic and dopaminergic neurotransmission in patients with obsessive–compulsive disorder (OCD). We investigated both serotonergic and dopaminergic neurotransmission in 9 drug-naïve dogs with compulsive behaviour, as a potential model for human OCD. Single photon emission computed tomography was used with 123I-R91150 and 123I-FP-CIT, in combination with 99mTc-ECD brain perfusion co-registration, to measure the serotonin (5-HT) 2A receptor, dopamine transporter (DAT) and serotonin transporter (SERT) availability. Fifteen normally behaving dogs were used as reference group. Significantly lower 5-HT2A receptor radioligand availability in frontal and temporal cortices (bilateral) was observed. Further, in 78% of the compulsive dogs abnormal DAT ratios in left and right striatum were demonstrated. Interestingly, both increased and decreased DAT ratios were observed. Finally, significantly lower subcortical perfusion and (hypo)thalamic SERT availability were observed in the compulsive dogs. This study provides evidence for imbalanced serotonergic and dopaminergic pathways in the pathophysiology of compulsions in dogs. The similarities with the altered neurotransmission in human OCD provide construct validity for this non-induced, natural canine model, suggesting its usefulness for future investigations of the pathophysiology of human OCD as well as the effectiveness of psychopharmacological interventions.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.