دانلود مقاله ISI انگلیسی شماره 41263
عنوان فارسی مقاله

آستروسیتی IL-6 واسطه فعالیت حرکتی، اکتشاف، اضطراب، یادگیری و رفتار اجتماعی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
41263 2015 11 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Astrocytic IL-6 mediates locomotor activity, exploration, anxiety, learning and social behavior
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Hormones and Behavior, Volume 73, July 2015, Pages 64–74

کلمات کلیدی
اضطراب - آستروسیت - رفتار اکتشافی - صفحه سوراخ دار - IL-6 - بقا داخل رحمی - یادگیری فضایی - موریس آب پیچ و خم - موش تراریخته
پیش نمایش مقاله
پیش نمایش مقاله آستروسیتی IL-6 واسطه فعالیت حرکتی، اکتشاف، اضطراب، یادگیری و رفتار اجتماعی

چکیده انگلیسی

Interleukin-6 (IL-6) is a major cytokine in the central nervous system, secreted by different brain cells and with roles in a number of physiological functions. We herewith confirm and expand the importance of astrocytic production of and response to IL-6 by using transgenic mice deficient in astrocytic IL-6 (Ast-IL-6 KO) or in its receptor (Ast-IL-6R KO) in full C57Bl/6 genetic background. A major prosurvival effect of astrocytic IL-6 at early ages was clearly demonstrated. Robust effects were also evident in the control of activity and anxiety in the hole-board and elevated plus-maze, and in spatial learning in the Morris water-maze. The results also suggest an inhibitory role of IL-6 in the mechanism controlling the consolidation of hippocampus-dependent spatial learning. Less robust effects of astrocytic IL-6 system were also observed in despair behavior in the tail suspension test, and social behavior in the dominance and resident–intruder tests. The behavioral phenotype was highly dependent on age and/or sex in some cases. The phenotype of Ast-IL-6R KO mice mimicked only partially that of Ast-IL-6KO mice, which indicates both a role of astrocytes in behavior and the participation of other cells besides astrocytes. No evidences of altered function of the hypothalamic–pituitary–adrenal axis were observed. These results demonstrate that astrocytic IL-6 (acting at least partially in astrocytes) regulates normal behavior in mice.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.