دانلود مقاله ISI انگلیسی شماره 46838
عنوان فارسی مقاله

آموزش خاموش سازی به عنوان یک تعدیل کننده اثر دی سیکلوسرین برای افزایش مواجهه درمانی در اختلال پس از استرس

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
46838 2015 5 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Extinction learning as a moderator of d-cycloserine efficacy for enhancing exposure therapy in posttraumatic stress disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Anxiety Disorders, Volume 34, August 2015, Pages 63–67

کلمات کلیدی
دی-سیکلوسرین - اختلال استرس پس از سانحه - آموزش خاموش سازی - میانه روی
پیش نمایش مقاله
پیش نمایش مقاله آموزش خاموش سازی به عنوان یک تعدیل کننده اثر دی سیکلوسرین برای افزایش مواجهه درمانی در اختلال پس از استرس

چکیده انگلیسی

Augmentation of exposure therapy with d-cycloserine (DCS) has proven efficacious across anxiety disorders, although results in PTSD have been mixed. Work in animals and anxiety-disordered patients suggest that the potentiating effects of DCS are dependent on the level of extinction learning during extinction training and exposure treatment, respectively. The aim of the current study was to replicate and extend previous work by examining the association between the degree of extinction learning and DCS efficacy in our randomized clinical trial on DCS (50 mg) versus placebo enhancement of exposure therapy in a chronic mixed-trauma PTSD sample (N = 67; de Kleine, Hendriks, Kusters, Broekman, & van Minnen, 2012). The decline in subjective units of distress ratings collected during and across the exposure sessions were evaluated as indices of extinction learning. First, we examined whether extinction learning during an exposure session moderated DCS effects on self-reported PTSD symptoms at the next session. Second, we examined whether averaged extinction learning over the course of treatment interacted with group assignment to predict change over time and post treatment outcome. We did not find evidence that DCS effects were moderated by the degree of extinction learning, although, extinction learning was related to outcome regardless of group assignment. In PTSD, not one extinction-learning index has been consistently linked to DCS enhanced exposure treatment outcome. More (experimental) work needs to been done to unravel the complex interplay between extinction learning and DCS enhancement, especially in PTSD patients.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.