دانلود مقاله ISI انگلیسی شماره 50954
عنوان فارسی مقاله

ارتباطات عصبی و مدولاسیون سروتونرژیک بازداری رفتاری و پاداش در افراد سالم و ضد اجتماعی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
50954 2010 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Neuronal correlates and serotonergic modulation of behavioural inhibition and reward in healthy and antisocial individuals
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 44, Issue 3, February 2010, Pages 123–131

کلمات کلیدی
اختلال شخصیت ضد اجتماعی؛ مهار رفتاری؛ جایزه؛ fMRI؛ سروتونین
پیش نمایش مقاله
پیش نمایش مقاله ارتباطات عصبی و مدولاسیون سروتونرژیک بازداری رفتاری و پاداش در افراد سالم و ضد اجتماعی

چکیده انگلیسی

Individuals with antisocial personality disorder (ASPD) are impulsive and show impairment in reinforcement processing. There is increasing evidence for a neurobiological basis of psychopathy, which shares some of the characteristics of ASPD, but research on the neuronal correlates of neuropsychological processes in ASPD remains limited. Furthermore, no research has examined the effects of serotonergic manipulation on brain activations in antisocial groups. In this study, 25 male participants with ASPD (mean age 42.1) and 32 male control participants (mean age 30.5; 25 participants providing usable scans) were randomly allocated to receive the 5-HT2C-agonist mCPP or placebo. Participants were scanned using functional magnetic resonance imaging (fMRI) during a behavioural inhibition (Go/NoGo) and a reward task. In comparison to healthy controls the ASPD group showed reduced task related activations in the dorsolateral prefrontal cortex (DLPFC) but increased signal in the pre/subgenual anterior cingulate cortex (ACC) in the Go/No-Go task and increased activation in OFC in the reward task. mCPP modulated brain responses in both tasks in the whole group. Interactions between group and drug occured in bilateral OFC, caudate and ventral pallidum during the reward task but no significant interactions were found in the Go/No-Go task. This suggests that ASPD involves altered serotonin modulation of reward, but not motor inhibition pathways. These findings suggest that ASPD involves altered DLPFC, ACC and OFC function. Altered serotonergic modulation of reward pathways seen in the ASPD group raises the possibility that targeting serotonin systems may be therapeutic.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.