دانلود مقاله ISI انگلیسی شماره 50977
عنوان فارسی مقاله

تنوع جمعیت در فعالیت اعصاب و غدد با بازداری رفتاری و ساختار نیمکره مغز در میمونهای جوان در ارتباط است

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
50977 2014 12 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Population variation in neuroendocrine activity is associated with behavioral inhibition and hemispheric brain structure in young rhesus monkeys
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 47, September 2014, Pages 56–67

کلمات کلیدی
کورتیزول؛ عاطفی،؛ میمون؛ آنالیز خوشه ای؛ بازداری رفتاری؛ ساختار مغز؛ تقارن نیمکره غربی
پیش نمایش مقاله
پیش نمایش مقاله تنوع جمعیت در فعالیت اعصاب و غدد با بازداری رفتاری و ساختار نیمکره مغز در میمونهای جوان در ارتباط است

چکیده انگلیسی

Population variation in hypothalamic-pituitary-adrenal (HPA) activity and reactivity was assessed in a healthy sample of 48 juvenile rhesus monkeys. Cluster analysis of the HPA profiles revealed four distinct neuroendocrine phenotypes based on six indices of HPA functioning. Behavioral reactivity was also evaluated in response to novel stimuli, and revealed marked differences between animals in the highest- and lowest-cortisol clusters. Specifically, animals in the high-cortisol cluster showed larger stress-induced cortisol responses and blunted feedback sensitivity to dexamethasone. They were also emotionally reactive, displayed more aggressive behaviors, and were less likely to approach novel objects. In contrast, monkeys in the low-cortisol cluster were more likely to approach and explore novel objects. Representative animals with high or low cortisol profiles were scanned with Magnetic Resonance Imaging to evaluate structural differences in global and regional gray matter (GM) and white matter (WM) volumes. Monkeys with higher cortisol reactivity evinced less hemispheric brain asymmetry, due to decreased GM in the right hemisphere. Stress reactivity was inversely related to global GM and positively related to total cerebrospinal fluid volume. This inverse relationship was also observed in several stress-sensitive regions, including prefrontal and frontal cortices. Our study demonstrates that population variation in pituitary-adrenal activity is related to behavioral disposition and cerebral structure in this nonhuman primate species.

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