دانلود مقاله ISI انگلیسی شماره 58494
عنوان فارسی مقاله

لیپوپلی ساکارید رفلکس وحشت زدگی صوتی در موش را تحت تاثیر قرار نمی دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
58494 2008 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Lipopolysaccharide does not affect acoustic startle reflex in mice
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Brain, Behavior, and Immunity, Volume 22, Issue 1, January 2008, Pages 74–79

کلمات کلیدی
رفلکس وحشت زدگی صوتی؛ مهار پیش پالس؛ لیپوپلی ساکارید؛
پیش نمایش مقاله
پیش نمایش مقاله لیپوپلی ساکارید رفلکس وحشت زدگی صوتی در موش را تحت تاثیر قرار نمی دهد

چکیده انگلیسی

Bacterial endotoxin (lipopolysaccharide; LPS) evokes in rodents an adaptive sickness behavior. It also produces changes in stress hormones secretion and activity of brain serotonergic and noradrenergic systems that have been implicated in stress responses, fear, and anxiety. Acoustic startle reflex (ASR) is regarded as a protective behavioral response that is enhanced in threatening situations or following an aversive event, and it can be modulated by physiological and emotional state of an animal. Effects of intraperitoneal injections of LPS on ASR, prepulse inhibition (PPI), locomotor activity in open field, and blood plasma corticosterone concentration were studied in lines of mice that display high (HA line) or low (LA line) swim stress-induced analgesia and also differ in emotional behaviors, including the magnitude of ASR. In both lines LPS produced robust sickness behavior, as evidenced by a decrease in locomotion and body weight, and an increase in corticosterone concentration. However, in neither line LPS injections affected responses to acoustic stimuli as assessed by the ASR and PPI magnitudes. The findings suggest that in sickness behavior induced by LPS the protective responses to salient environmental stimuli are not impaired. The significance of this finding for the concept of sickness behavior is discussed.

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