رفتارهای اعتیاد آور و صفات شخصیتی در معرض اعتیاد: ارتباط با مشخصات ژنتیکی دوپامین چندژنی
|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|59106||2013||7 صفحه PDF||سفارش دهید||6462 کلمه|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Addictive Behaviors, Volume 38, Issue 7, July 2013, Pages 2306–2312
The purpose of this study was to examine reward-related genetic risk for addictive behaviors in a healthy community sample (n = 217) of men and women. We tested a mediation model predicting that a quantitative multilocus genetic profile score – reflecting the additive effects of alleles known to confer relatively increased dopamine signaling in the ventral striatum – would relate positively to a composite measure of addictive behaviors, and that this association would be mediated by personality traits consistently associated with addiction disorders. Our model was strongly supported by the data, and accounted for 24% of the variance in addictive behaviors. These data suggest that brain reward processes tend to exert their influence on addiction risk by their role in the development of relatively stable personality traits associated with addictive behaviors.