کورتیزول تمایز عصبی در طول اکتساب ترس و انقراض در زنان جوان احتیاطی آگاه را افزایش می دهد
|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|59406||2010||10 صفحه PDF||سفارش دهید||9419 کلمه|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Neurobiology of Learning and Memory, Volume 94, Issue 3, October 2010, Pages 392–401
Previously, we observed cortisol induced enhancement of neural fear acquisition in women. Yet, less is known about cortisol effects on neural fear extinction. Via differential fear conditioning, we explored cortisol effects on acquisition and extinction. Twenty contingency aware women taking monophasic oral contraceptives were included; 10 received placebo, 10 cortisol before conditioning. Group differences emerged in anterior cingulate cortex (ACC), hippocampus, and – as trend – in insula and thalamus during acquisition and in hippocampus, thalamus, and – as trend – in amygdala, insula, and ACC during extinction. During acquisition group differences were due to higher responses to the CS+ than to the CS− in the cortisol group. Notably, during extinction, group differences were due to higher responses to the CS− than to the CS+ in this group. Thus, cortisol induced a fear acquisition and extinction specific enhanced neural differentiation.