دانلود مقاله ISI انگلیسی شماره 59406
عنوان فارسی مقاله

کورتیزول تمایز عصبی در طول اکتساب ترس و انقراض در زنان جوان احتیاطی آگاه را افزایش می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
59406 2010 10 صفحه PDF سفارش دهید 9419 کلمه
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Cortisol enhances neural differentiation during fear acquisition and extinction in contingency aware young women
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 94, Issue 3, October 2010, Pages 392–401

کلمات کلیدی
هیجانی؛ یادگیری انقراض؛ یادگیری ترس ؛واکنش غیرشرطی؛
کلمات کلیدی انگلیسی
ACC, anterior cingulate cortex; CS, conditioned stimulus; CS+, conditioned stimulus predicting the electrical stimulation; CS−, conditioned stimulus predicting the absence of the electrical stimulation; FIR, first interval response; fMRI, functional magnetic resonance imaging; FWE, family-wise error; GC, glucocorticoid; GR, glucocorticoid receptor; HPA, hypothalamus–pituitary–adrenal; mPFC, medial prefrontal cortex; MR, mineralocorticoid receptor; OC, oral contraceptives; OFC, orbitofrontal cortex; ROI, region of interest; SCR, skin conductance response; SIR, second interval response; UCR, unconditioned response; UCS, unconditioned stimulusCortisol; Emotion; Extinction learning; Fear learning; fMRI; Stress hormones
پیش نمایش مقاله
پیش نمایش مقاله کورتیزول تمایز عصبی در طول اکتساب ترس و انقراض در زنان جوان احتیاطی آگاه را افزایش می دهد

چکیده انگلیسی

Previously, we observed cortisol induced enhancement of neural fear acquisition in women. Yet, less is known about cortisol effects on neural fear extinction. Via differential fear conditioning, we explored cortisol effects on acquisition and extinction. Twenty contingency aware women taking monophasic oral contraceptives were included; 10 received placebo, 10 cortisol before conditioning. Group differences emerged in anterior cingulate cortex (ACC), hippocampus, and – as trend – in insula and thalamus during acquisition and in hippocampus, thalamus, and – as trend – in amygdala, insula, and ACC during extinction. During acquisition group differences were due to higher responses to the CS+ than to the CS− in the cortisol group. Notably, during extinction, group differences were due to higher responses to the CS− than to the CS+ in this group. Thus, cortisol induced a fear acquisition and extinction specific enhanced neural differentiation.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.