دانلود مقاله ISI انگلیسی شماره 59439
عنوان فارسی مقاله

اثر ملاتونین بر مهار پیش پالس‌های، عادت و حساسیت رفلکس وحشت زدگی انسان در داوطلبان سالم

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
59439 2014 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Effects of melatonin on prepulse inhibition, habituation and sensitization of the human startle reflex in healthy volunteers
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 216, Issue 3, 30 May 2014, Pages 418–423

کلمات کلیدی
راهگاهی حسی؛ اسکیزوفرنی؛ الکترومیوگرافی؛
پیش نمایش مقاله
پیش نمایش مقاله اثر ملاتونین بر مهار پیش پالس‌های، عادت و حساسیت رفلکس وحشت زدگی انسان در داوطلبان سالم

چکیده انگلیسی

Prepulse inhibition of the startle reflex (PPI) is an operational measure of sensorimotor gating, which is demonstrated to be impaired in patients with schizophrenia. In addition, a disruption of the circadian rhythm together with blunted melatonin secretion is regularly found in patients with schizophrenia and it is theorized that these may contribute to their attentional deficits. The aim of this study was to assess the effects of acute melatonin on healthy human sensorimotor gating. Twenty-one healthy male volunteers were administered melatonin or placebo after which their levels of PPI were assessed. Melatonin significantly reduced startle magnitude and ratings of alertness, but did not influence PPI, nor sensitization and habituation. However, when taking baseline scores in consideration, melatonin significantly increased PPI in low scoring individuals while significantly decreasing it in high scoring individuals in low intensity prepulse trialtypes only. In addition, subjective ratings of alertness correlated with PPI. The results suggest that melatonin has only minor influences on sensorimotor gating, habituation and sensitization of the startle reflex of healthy males. The data do indicate a relationship between alertness and PPI. Further research examining the effects of melatonin on these processes in patients with schizophrenia is warranted.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.