دانلود مقاله ISI انگلیسی شماره 60301
عنوان فارسی مقاله

فراتر از HPA محور: نقش گیرنده های هورمون استروئیدی غدد جنسی در تعدیل واکنشهای مربوط به استرس در مدل حیوانی اختلال PTSD

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
60301 2015 14 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Beyond the HPA-axis: The role of the gonadal steroid hormone receptors in modulating stress-related responses in an animal model of PTSD
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 25, Issue 6, June 2015, Pages 944–957

کلمات کلیدی
اختلال استرس پس از سانحه؛ HPA-محور - HPG محور؛ گیرنده های آندروژن؛ گیرنده استروژن α ؛ تستوسترون
پیش نمایش مقاله
پیش نمایش مقاله فراتر از HPA محور: نقش گیرنده های هورمون استروئیدی غدد جنسی در تعدیل واکنشهای مربوط به استرس در مدل حیوانی اختلال PTSD

چکیده انگلیسی

The hypothalamic–pituitary–adrenal (HPA) axis, which plays a major role in the response to stress, and the hypothalamic–pituitary–gonadal (HPG) axis are closely linked with the ability to inhibit the other. Testosterone, a product of the HPG, has many beneficial effects beyond its functions as a sex hormone including anti-anxiety properties. In this study we examined the effect of stress exposure on gonadal hormones, and their efficacy in modulating anxiety-like response in an animal model of PTSD. Male rats were exposed to predator scent stress, followed by analysis of brain expression of androgen receptor (AR) receptor and estrogen receptor α (ERα). The behavioral effects of immediate treatment with testosterone, testosterone receptor antagonist (flutamide) or vehicle were evaluated using the elevated plus-maze, acoustic startle response and trauma-cue response. Levels of circulating corticosterone and testosterone were also measured after treatment. The behavioral effects of delayed testosterone treatment were explored in the same manner. We report that animals whose behavior was extremely disrupted (EBR) selectively displayed significant down-regulation of AR and ERα in the hippocampus. Immediate treatment with flutamide or delayed treatment with testosterone significantly increased prevalence rates of minimal behavioral response (MBR) and decreased prevalence of EBR with favorable behavioral results. Testosterone levels were higher in control un-exposed animals, while corticosterone was higher in control exposed animals. This study suggests that gonadal steroid hormones are involved in the neurobiological response to predator scent stress and thus warrant further study as a potential therapeutic avenue for the treatment of anxiety-related disorders.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.