دانلود مقاله ISI انگلیسی شماره 60568
عنوان فارسی مقاله

واکنشهای تنهایی و التهاب و اعصاب و غدد مربوط به استرس در مردان و زنان مسن

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
60568 2012 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 37, Issue 11, November 2012, Pages 1801–1809

کلمات کلیدی
تنهایی؛ سیتوکین؛ اینترلوکین 6؛ آنتاگونیست گیرنده اینترلوکین 1؛ مونوسیت پروتئین کموتاکتیک 1؛ کورتیزول بزاقی؛ استرس های روانی
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پیش نمایش مقاله واکنشهای تنهایی و التهاب و اعصاب و غدد مربوط به استرس در مردان و زنان مسن

چکیده انگلیسی

Loneliness is a predictor of mortality and increased cardiovascular morbidity. Inflammation is a potential pathway through which loneliness might impact health. The aim of the study was to investigate the relationship between loneliness and inflammatory interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1Ra) and monocyte chemotactic protein-1 (MCP-1) responses to standardized mental stress. A secondary purpose was to evaluate whether individual variations in cortisol responses influenced the hypothesised relationship between loneliness and inflammation. Saliva samples and blood were taken from 524 healthy middle-aged men and women from the Whitehall II cohort at baseline, immediately after the stress tasks and 45 min later. Loneliness was measured using the revised UCLA loneliness scale. Greater loneliness was associated with larger IL-6 (p = 0.044) and IL-1Ra (p = 0.006) responses to psychological stress and higher MCP-1 (p < 0.001) levels in women, independently of age, grade of employment, body mass index and smoking status. No associations were observed in men. Cortisol responsivity was inversely related to loneliness in women, with the odds of being a cortisol responder decreasing with increased loneliness independently of covariates (p = 0.008). The impact of loneliness on health in women may be mediated in part through dysregulation of inflammatory and neuroendocrine systems.

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