دانلود مقاله ISI انگلیسی شماره 60716
عنوان فارسی مقاله

نقش توده سیاه در تثبیت شرطی سازی ترس

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
60716 2007 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Substantia nigra role in fear conditioning consolidation
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 87, Issue 1, January 2007, Pages 133–139

کلمات کلیدی
زمینه - غیر فعال سازی کاربردی؛ واکنش های آزارنده؛
پیش نمایش مقاله
پیش نمایش مقاله نقش توده سیاه در تثبیت شرطی سازی ترس

چکیده انگلیسی

The substantia nigra (SN) is known to be involved in the memorization of several conditioned responses. To investigate the role of the SN in fear conditioning consolidation this neural site was subjected to fully reversible tetrodotoxin (TTX) inactivation during consolidation in adult male Wistar rats which had undergone fear training to acoustic CS and context. TTX was stereotaxically administered to different groups of rats at increasing intervals after the acquisition session. Memory was assessed as conditioned freezing duration measured during retention testing, always performed 72 and 96 h after TTX administration. In this way there was no interference with normal SN function during either acquisition or retrieval phases, so that any amnesic effect could be due only to consolidation disruption. The results show that SN functional integrity is necessary for contextual fear response consolidation up to the 24-h after-acquisition delay. On the contrary SN functional integrity was shown not to be necessary for the consolidation of acoustic CS fear responses. The present findings help to elucidate the role of the SN in memory consolidation and better define the neural circuits involved in fear memories.

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