دانلود مقاله ISI انگلیسی شماره 60725
عنوان فارسی مقاله

سرکوب P50 در پارادایم شرطی سازی ترس تبعیض انسان با استفاده از سیگنال های خطر و ایمنی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
60725 2012 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
P50 suppression in human discrimination fear conditioning paradigm using danger and safety signals
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : International Journal of Psychophysiology, Volume 84, Issue 1, April 2012, Pages 26–32

کلمات کلیدی
اضطراب؛ راهگاهی حسی؛ سرکوب P50؛ شرطی سازی ترس کلاسیک؛ انقراض ترس
پیش نمایش مقاله
پیش نمایش مقاله سرکوب P50 در پارادایم شرطی سازی ترس تبعیض انسان با استفاده از سیگنال های خطر و ایمنی

چکیده انگلیسی

Auditory P50 suppression, which is assessed using a paired auditory stimuli (S1 and S2) paradigm to record the P50 mid-latency evoked potential, is assumed to reflect sensory gating. Recently, P50 suppression deficits were observed in patients with anxiety disorders, including panic disorder, post-traumatic stress disorder and obsessive–compulsive disorder, as we previously reported. The processes of fear conditioning are thought to play a role in the pathophysiology of anxiety disorders. In addition, we found that the P50 sensory gating mechanism might be physiologically associated with fear conditioning and extinction in a simple human fear-conditioning paradigm that involved a light signal as a conditioned stimulus (CS +). Our objective was to investigate the different patterns of P50 suppression in a discrimination fear-conditioning paradigm with both a CS + (danger signal) and a CS − (safety signal). Twenty healthy volunteers were recruited. We measured the auditory P50 suppression in the control (baseline) phase, in the fear-acquisition phase, and in the fear-extinction phase using a discrimination fear-conditioning paradigm. Two-way (CSs vs. phase) Analysis of variance with repeated measures demonstrated a significant interaction between the two factors. Post-hoc LSD analysis indicated that the P50 S2/S1 ratio in the CS + acquisition phase was significantly higher than that in the CS − acquisition phase. These results suggest that the auditory P50 sensory gating might differ according to the cognition of the properties (potentially dangerous or safe) of the perceived signal.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.