دانلود مقاله ISI انگلیسی شماره 60752
عنوان فارسی مقاله

ناهمسانی استرس شرطی سازی ترس در مردان و زنان را تحت تاثیر قرار می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
60752 2013 13 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Stress differentially affects fear conditioning in men and women ☆
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 38, Issue 11, November 2013, Pages 2529–2541

کلمات کلیدی
آمیگدال؛ کمربندی قدامی؛ کورتیزول؛ یادگیری ترس ؛ fMRI؛ نوکلئوس اکومبنس؛ قرص های ضد بارداری؛ تفاوت جنسیت؛ هورمون های استرس؛ TSST
پیش نمایش مقاله
پیش نمایش مقاله ناهمسانی استرس شرطی سازی ترس در مردان و زنان را تحت تاثیر قرار می دهد

چکیده انگلیسی

Stress and fear conditioning processes are both important vulnerability factors in the development of psychiatric disorders. In behavioral studies considerable sex differences in fear learning have been observed after increases of the stress hormone cortisol. But neuroimaging experiments, which give insights into the neurobiological correlates of stress × sex interactions in fear conditioning, are lacking so far. In the current functional magnetic resonance imaging (fMRI) study, we tested whether a psychosocial stressor (Trier Social Stress Test) compared to a control condition influenced subsequent fear conditioning in 48 men and 48 women taking oral contraceptives (OCs). One of two pictures of a geometrical figure was always paired (conditioned stimulus, CS+) or never paired (CS−) with an electrical stimulation (unconditioned stimulus). BOLD responses as well as skin conductance responses were assessed. Sex-independently, stress enhanced the CS+/CS− differentiation in the hippocampus in early acquisition but attenuated conditioned responses in the medial frontal cortex in late acquisition. In early acquisition, stress reduced the CS+/CS− differentiation in the nucleus accumbens in men, but enhanced it in OC women. In late acquisition, the same pattern (reduction in men, enhancement in OC women) was found in the amygdala as well as in the anterior cingulate. Thus, psychosocial stress impaired the neuronal correlates of fear learning and expression in men, but facilitated them in OC women. A sex-specific modulation of fear conditioning after stress might contribute to the divergent prevalence of men and women in developing psychiatric disorders.

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