دانلود مقاله ISI انگلیسی شماره 69477
عنوان فارسی مقاله

اثر ضد افسردگی مانند ترانس رزوراترول در مدل استرس مزمن: شواهد رفتاری و عصب شیمیایی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
69477 2013 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
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عنوان انگلیسی
Antidepressant-like effect of trans-resveratrol in chronic stress model: Behavioral and neurochemical evidences
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 47, Issue 3, March 2013, Pages 315–322

کلمات کلیدی
ترانس رزوراترول؛ استرس مزمن غیر قابل پیش بینی - شاتل جعبه؛ آزمون رجحان سوکروز؛ مونوآمین؛ منوآمین
پیش نمایش مقاله
پیش نمایش مقاله اثر ضد افسردگی مانند ترانس رزوراترول در مدل استرس مزمن: شواهد رفتاری و عصب شیمیایی

چکیده انگلیسی

Trans-resveratrol is a phenolic compound enriched in polygonum cuspidatum and has diverse biological activities. There is only limited information about the antidepressant-like effect of trans-resveratrol. The present study investigated whether trans-resveratrol has antidepressant-like activity in rats exposed to chronic stress by using two behavioral tasks, shuttle box and sucrose preference tests. The monoamines (5-HT, noradrenaline and dopamine) and their metabolites as well as monoamine oxidase (MAO) enzyme activities in different brain regions were also measured. Compared to unstressed rats, those exposed to chronic stress paradigm showed performance deficits in the shuttle box, reduced sucrose preference, less weight gain and the increase in the ratio of adrenal gland to body weight, which were reversed by chronic treatment with trans-resveratrol (40 and 80 mg/kg, i.g.). The neurochemical assay showed that higher dose of trans-resveratrol (80 mg/kg) produced a marked increase of 5-HT levels in three brain regions, the frontal cortex, hippocampus and hypothalamus. Noradrenaline and dopamine levels were also increased both in the frontal cortex and striatum. Furthermore, chronic treatment with trans-resveratrol was found to inhibit monoamine oxidase-A (MAO-A) activity in all the four brain regions, particularly in the frontal cortex and hippocampus; while MAO-B activity was not affected. These findings indicate that the antidepressant-like effect of trans-resveratrol involves the regulation of the central serotonin and noradrenaline levels and the related MAO-A activities.

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