دانلود مقاله ISI انگلیسی شماره 69494
عنوان فارسی مقاله

ازدحام بیش از حد اجتماعی به عنوان یک مدل استرس مزمن که چاقی در موش را افزایش می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
69494 2015 13 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Social overcrowding as a chronic stress model that increases adiposity in mice
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 51, January 2015, Pages 318–330

کلمات کلیدی
استرس اجتماعی؛ چاقی؛ اضطراب؛ بافت چربی سفید
پیش نمایش مقاله
پیش نمایش مقاله ازدحام بیش از حد اجتماعی به عنوان یک مدل استرس مزمن که چاقی در موش را افزایش می دهد

چکیده انگلیسی

Stress is a widely recognized risk factor for psychiatric and metabolic disorders. A number of animal models utilizing various stressors have been developed to facilitate our understanding in the pathophysiology of stress-related dysfunctions. The most commonly used chronic stress paradigms include the unpredictable chronic mild stress paradigm, the social defeat paradigm and the social deprivation paradigm. Here we assess the potential of social crowding as an alternative chronic stress model to study the effects on affective behaviors and metabolic disturbances. Ten-week-old male C57BL/6 mice were housed in groups of four (control) or eight (social crowding; SC) in standard cage for 9 weeks. Exploration, anxiety- and depressive-like behaviors were assessed in the open field test, the elevated T-maze, the novelty-suppressed feeding test and the forced swim test. SC mice exhibited a modest anxiety-like phenotype without change in depressive-like behaviors. Nine weeks of social crowding did not affect the body weight, but robustly increased adiposity as determined by increased mass of fat depots. Consistent with the increased fat content, serum leptin was markedly elevated in the SC mice. Specific changes in gene expression were also observed in the hypothalamus and the white adipose tissue following SC housing. Our study demonstrates the potential of social crowding as an alternative model for the study of stress-related metabolic and behavioral dysfunctions.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.