دانلود مقاله ISI انگلیسی شماره 69529
عنوان فارسی مقاله

استرس حاد و مزمن غلظت DHEAS در میمون های رزوس را افزایش می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
69529 2010 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Acute and chronic stress increase DHEAS concentrations in rhesus monkeys
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 35, Issue 7, August 2010, Pages 1055–1062

کلمات کلیدی
هیپوتالاموس هیپوفیز آدرنال محور؛ سولفات کورتیزول؛ فشار؛ میمون رزوس؛ دگزامتازون
پیش نمایش مقاله
پیش نمایش مقاله استرس حاد و مزمن غلظت DHEAS در میمون های رزوس را افزایش می دهد

چکیده انگلیسی

Most studies on the stress-responsiveness of the hypothalamic–pituitary–adrenal (HPA) axis have focused on glucocorticoids, while few studies have investigated the adrenal secretion of dehydroepiandrosterone sulfate (DHEAS), which is unique to primates. Monkeys were chair-restrained for 2 h per day for seven consecutive days, and blood samples were collected upon placement in the chair, and at 15, 30, 60 and 120 min later. Like cortisol, DHEAS concentrations increased throughout the initial session of chair restraint (acute stress). Unlike the cortisol response, which decreased after repeated exposure to the stressor, the DHEAS response was sustained throughout the seventh session of restraint (chronic stress) and response to the seventh session of restraint did not differ from the DHEAS response to the initial session. Like cortisol, DHEAS concentrations showed a diurnal rhythm with higher concentrations in the morning compared to the evening and a decrease in response to dexamethasone (DEX) administration. After repeated exposure to the stressor, the suppression of DHEAS in response to dexamethasone was more complete, suggesting an increase in negative feedback sensitivity. These data show that DHEAS concentrations increase in response to both acute and chronic (repeated) stress and provide another measure of HPA activity that parallels cortisol during acute responses to stress but diverges in chronic or repeated stress.

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